Diversification in Toxicology — Man and Environment

1. Front Matter

   Pages I-X

   PDF

2. The Gerhard Zbinden Memorial Lecture

   1. Front Matter

      Pages 1-1

      PDF

   2. Molecular Basis of Halothane Hepatitis

      • Josef Gut

      Pages 3-17

3. Plenary Lecture

   1. Front Matter

      Pages 19-19

      PDF

   2. Receptor -Mediated Toxicity

      • Jan-Åke Gustafsson, George Kuiper, Eva Enmark, Eckhardt Treuter, Joseph Rafter

      Pages 21-28

4. Animals as Models in Toxicology: Animal Welfare and Ethics

   1. Front Matter

      Pages 29-29

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   2. Animal Burdens versus Human Benefits — How Should the Ethical Limits be Drawn for Use of Animals as Models in Toxicology?

      • Peter Sandøe, Ove Svendsen

      Pages 31-40

   3. Behavior of Laboratory Animals under Unnatural Conditions

      • Jan Ladewig

      Pages 41-46

   4. The Impact of Stress and Discomfort on Experimental Outcome

      • Wolf H. Weihe

      Pages 47-59

   5. Priorities in the Development of Alternative Methodologies in the Pharmaceutical Industry

      • M. R. Jackson

      Pages 61-70

   6. Development and Strategic Use of Alternative Tests in Assessing the Hazard of Chemicals

      • Iain F. H. Purchase

      Pages 71-80

5. Ecotoxicological Risk Assessment

   1. Front Matter

      Pages 81-81

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   2. Soil Ecotoxicological Risk Assessment: How to Find Avenues in a Pitch Dark Labyrinth

      • H. Eijsackers

      Pages 83-96

   3. Monitoring and Risk Assessment for Endocrine Disruptors in the Aquatic Environment: A Biomarker Approach

      • P. Bjerregaard, B. Korsgaard, L. B. Christiansen, K. L. Pedersen, L. J. Christensen, S. N. Pedersen et al.

      Pages 97-107

6. Effects of Environmental Chemicals on Reproduction

   1. Front Matter

      Pages 109-109

      PDF

   2. Developmental and Reproductive Toxicity of Persistent Environmental Pollutants

      • Ingvar Brandt, Cecilia Berg, Krister Halldin, Björn Brunström

      Pages 111-119

   3. Effects of the In Vitro Chemical Environment During Early Embryogenesis on Subsequent Development

      • Donald Rieger

      Pages 121-129

   4. Influence of Hormones and Hormone Antagonists on Sexual Differentiation of the Brain

      • Klaus D. Döhler

      Pages 131-141

   5. Reproductive Effects from Oestrogen Activity in Polluted Water

      • John P. Sumpter

      Pages 143-150

   6. Effects of Chemical-Induced DNA Damage on Male Germ Cells

      • J. A. Holme, C. Bjørge, M. Trbojevic, A.-K. Olsen, G. Brunborg, E. J. Søderlund et al.

      Pages 151-160

This volume contains the main papers presented at the 1997 EUROTOX Congress, Århus, Denmark, 24-28 June 1997. Diversification in toxicology is seen as the application of basic science to such diverse areas as man and his environment. The pressing issues which have been dealt with not only include reproductive effects of environmental chemicals ("xenoestrogens"), but also receptor-mediated toxic responses, new frontiers in human and ecological toxicology, chemoprevention of cancer and molecular approaches in toxicological research. The practical and ethical facets of toxicology, e.g. ecotoxicological risk assessment, biomarkers of exposure, complex chemical mixtures as well as animal welfare and the ethics of animal experimentation, are also treated.

• DNA
• Lipid
• Oxidation
• cytochrome P450
• metabolism

• Intercantonal Office for the Control of Medicines(IOCM), Bern 9, Switzerland

  Jürg P. Seiler

• Risskov, Denmark

  Judith L. Autrup

• Steno Institute of Public Health, University of Åarhus, Åarhus C, Denmark

  Herman Autrup

Policies and ethics