Mechanism of Action of Antieukaryotic and Antiviral Compounds

1. Front Matter

   Pages I-XIII

   PDF

2. Anisomycin and Related Antibiotics

   • A. Jiménez, D. Vázquez

   Pages 1-19

3. Antitumor Platinum Compounds

   • J. J. Roberts

   Pages 20-84

4. 9-β-D-Arabinofuranosyladenine (AraA)

   • C. E. Cass

   Pages 85-109

5. 8-Azaguanine

   • D. Grunberger, G. Grunberger

   Pages 110-123

6. Bleomycin

   • C. W. Haidle, R. S. Lloyd

   Pages 124-154

7. Diphtheria Toxin and Exotoxin A from Pseudomonas aeruginosa

   • R. J. Collier

   Pages 155-172

8. Echinomycin, Triostin, and Related Antibiotics

   • M. J. Waring

   Pages 173-194

9. Ellipticine

   • K. W. Kohn, W. E. Ross, D. Glaubiger

   Pages 195-213

10. 2-Hydroxy-3-Alkyl-1,4-Naphthoquinones

    • J. G. Olenick

    Pages 214-222

11. Hydroxystilbamidine

    • B. Festy

    Pages 223-235

12. 5-Iodo-2′-Deoxyuridine

    • W. H. Prusoff, M. S. Chen, P. H. Fischer, T. S. Lin, G. T. Shiau

    Pages 236-261

13. Neocarzinostatin

    • I. H. Goldberg

    Pages 262-274

14. Nitracrine

    • M. Gniazdowski, J. Filipski, M. Chorąży

    Pages 275-297

15. Phleomycin

    • Ch. F. Earhart Jr.

    Pages 298-312

16. Polyene Antibiotics: Nystatin, Amphotericin B, and Filipin

    • R. W. Holz

    Pages 313-340

17. Protein and Glycoprotein Toxins That Inactivate the Eukaryotic Ribosome

    • D. Vázquez

    Pages 341-352

18. Quinine

    • F. E. Hahn

    Pages 353-362

19. Showdomycin

    • D. W. Visser, S. Roy-Burman

    Pages 363-371

20. Streptonigrin

    • N. S. Mizuno

    Pages 372-384

When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan­ isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto­ myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti­ cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti­ microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.

• Antibiotikum
• Antimykotikum
• Chemotherapeutikum
• Virostatikum
• alkaloids
• antibiotic
• antibiotics
• cancer
• environment
• research
• antibodies

• Department of the Army, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, USA

  Fred E. Hahn

Policies and ethics