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Steroid-Protein Interactions

  • Book
  • © 1971

Overview

Authors:
  1. Ulrich Westphal

    1. School of Medicine, University of Louisville, Louisville, USA

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Part of the book series: Monographs on Endocrinology (ENDOCRINOLOGY, volume 4)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Introduction

    • Ulrich Westphal
    Pages 1-3

  3. Early Studies on Interactions between Proteins and Small Molecules or Ions

    • Ulrich Westphal
    Pages 4-10

  4. First Observations on Reversible Binding of Steroids to Proteins

    • Ulrich Westphal
    Pages 11-14

  5. Basic Methods for Determination of Steroid-Protein Interactions

    • Ulrich Westphal
    Pages 15-52

  6. Characteristics of Steroid-Protein Interactions

    • Ulrich Westphal
    Pages 53-83

  7. Steroid Interactions with Serum Proteins Other than Specific Glycoproteins

    • Ulrich Westphal
    Pages 84-132

  8. Influence of Molecular Structure on Steroid Interaction with HSA and Other Proteins

    • Ulrich Westphal
    Pages 133-163

  9. Corticosteroid-Binding Globulin (CBG) of Man and Other Species

    • Ulrich Westphal
    Pages 164-236

  10. Influence of Various Endogenous Factors on CBG Activity in the Rat

    • Ulrich Westphal
    Pages 237-293

  11. CBG Activity in Mouse, Rabbit and Guinea Pig during Pregnancy and Lactation; PBG in the Guinea Pig

    • Ulrich Westphal
    Pages 294-314

  12. Isolation and Properties of CBG from Mammalian Sera

    • Ulrich Westphal
    Pages 315-355

  13. High-Affinity Binding of Estradiol and Testosterone to Serum Proteins

    • Ulrich Westphal
    Pages 356-374

  14. Interaction of Progesterone and Other Steroids with ฮฑ1-Acid Glycoprotein

    • Ulrich Westphal
    Pages 375-433

  15. Effect of Protein Binding on Hormonal Activity of Steroids

    • Ulrich Westphal
    Pages 434-445

  16. Steroid-Binding Immunoglobulins: Preparation, Properties and Application for Radioimmunoassay of Steroid Hormones

    • Ulrich Westphal
    Pages 446-462

  17. Notes on Steroid Interactions with Enzymes

    • Ulrich Westphal
    Pages 463-476

  18. Synopsis

    • Ulrich Westphal
    Pages 477-480

  19. Back Matter

    Pages 481-568
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Keywords

About this book

This is the story of steroid-protein interactions as one investigator sees it. Following the general concept of this monograph series, it emphasizes the results and interpretations obtained in the author's laboratory, and is therefore a subjective account. Recognizing, howยญ ever, that the discussion of the subject would be incomplete if the material were limited to one scientist's work, the essential achieveยญ ments of other investigators have been incorporated. An effort has thus been made to give a balanced presentation and to enable the reader to see in perspective the varied facets of the interactions between steroids and proteins. Since this is the first comprehensive treatment of the topic, it seems appropriate to go to the roots, and try to find out how it all started. The first chapters, therefore, take the reader to the laboratories of those who very early conceived the significance of the attachment of dyes, drugs, and other conspicuous molecules to those colloids called proteins. The discovery of the steroid hormones set the stage for meaningful investigation of their interaction with proteins of various origins and functions - a process which is continuing today with increasing vigor.

Authors and Affiliations

  • School of Medicine, University of Louisville, Louisville, USA

    Ulrich Westphal

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