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Voltage Gated Sodium Channels

  • Book
  • © 2014

Overview

Editors:
  1. Peter C. Ruben

    1. Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, Canada

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  • Gives unprecedented insight into the structural basis of sodium channel function
  • Explores sodium channels from the perspectives of their biophysical behavior
  • Written by leading experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 221)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Introduction to Sodium Channels

    • Colin H. Peters, Peter C. Ruben
    Pages 1-6

  3. The Voltage Sensor Module in Sodium Channels

    • James R. Groome
    Pages 7-31

  4. Slow Inactivation of Na+ Channels

    • Jonathan Silva
    Pages 33-49

  5. The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels

    • Jeffrey D. Calhoun, Lori L. Isom
    Pages 51-89

  6. Altered Sodium Channel Gating as Molecular Basis for Pain: Contribution of Activation, Inactivation, and Resurgent Currents

    • Angelika Lampert, Mirjam Eberhardt, Stephen G. Waxman
    Pages 91-110

  7. Regulation/Modulation of Sensory Neuron Sodium Channels

    • Mohamed Chahine, Michael E. O’Leary
    Pages 111-135

  8. The Role of Late I Na in Development of Cardiac Arrhythmias

    • Charles Antzelevitch, Vladislav Nesterenko, John C. Shryock, Sridharan Rajamani, Yejia Song, Luiz Belardinelli
    Pages 137-168

  9. Proton Modulation of Cardiac I Na: A Potential Arrhythmogenic Trigger

    • David K. Jones, Peter C. Ruben
    Pages 169-181

  10. Probing Gating Mechanisms of Sodium Channels Using Pore Blockers

    • Marcel P. Goldschen-Ohm, Baron Chanda
    Pages 183-201

  11. Animal Toxins Influence Voltage-Gated Sodium Channel Function

    • John Gilchrist, Baldomero M. Olivera, Frank Bosmans
    Pages 203-229

  12. Ubiquitylation of Voltage-Gated Sodium Channels

    • Cédric J. Laedermann, Isabelle Decosterd, Hugues Abriel
    Pages 231-250

  13. Pharmacological Insights and Quirks of Bacterial Sodium Channels

    • Ben Corry, Sora Lee, Christopher A. Ahern
    Pages 251-267

  14. Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels

    • Todd Scheuer
    Pages 269-291

  15. Back Matter

    Pages 293-295
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Keywords

About this book

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Editors and Affiliations

  • Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, Canada

    Peter C. Ruben

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