Editors:
- Written by leading experts in the field
- Addresses key aspects of the process of thymopoiesis
- Offers perspectives for understanding immunodeficiency and autoimmune diseases
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 373)
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Table of contents (6 chapters)
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Front Matter
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Back Matter
About this book
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
Editors and Affiliations
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Department of Developmental Immunology, Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany
Thomas Boehm
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Institute for Genome Research, Division of Experimental Immunology, University of Tokushima, Tokushima, Japan
Yousuke Takahama
Bibliographic Information
Book Title: Thymic Development and Selection of T Lymphocytes
Editors: Thomas Boehm, Yousuke Takahama
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-642-40252-4
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2014
Hardcover ISBN: 978-3-642-40251-7Published: 19 November 2013
Softcover ISBN: 978-3-662-51196-1Published: 23 August 2016
eBook ISBN: 978-3-642-40252-4Published: 06 November 2013
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 132
Number of Illustrations: 2 b/w illustrations, 9 illustrations in colour
Topics: Immunology, Human Physiology, Cytogenetics