Hematopoietic Cell Transplantation in Children with Cancer

1. Front Matter

   Pages i-x

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2. The History of Pediatric Hematopoietic Cell Transplantation Around the World

   • Jean E. Sanders, Peter F. Coccia, Dietrich Niethammer, Carmemm M. Bonfim, Peter J. Shaw, Chi-Kong Li

   Pages 1-22

3. Donor Sources and Donor Selection for Hematopoietic Cell Transplant

   • Ann E. Woolfrey, Vanderson Rocha

   Pages 23-40

4. Preparative Regimens

   • John E. Levine, Peter J. Shaw, Franklin O. Smith

   Pages 41-56

5. Graft Versus Host Disease: From Basics to the Clinic

   • Eva C. Guinan, Margaret L. MacMillan

   Pages 57-75

6. Pulmonary and Hepatic Complications of Hematopoietic Cell Transplantation

   • Gregory A. Yanik, Kenneth R. Cooke, Vincent T. Ho, Paul G. Richardson

   Pages 77-102

7. Opportunistic Infections in Pediatric Blood and Marrow Transplantation

   • Christopher C. Dvorak, William J. Steinbach

   Pages 103-131

8. Late Effects in Survivors After Hematopoietic Cell Transplantation in Childhood

   • K. Scott Baker, Anna Petryk, Vicki L. Fisher, Christine Duncan, Paul A. Carpenter

   Pages 133-169

9. Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia: Biology, Indications, and Outcomes

   • Michael A. Pulsipher, Elizabeth Raetz, Christina Peters

   Pages 171-220

10. Acute Myeloid Leukemia

    • John Horan, Henrik Hasle, Soheil Meshinchi

    Pages 221-249

11. Lymphomas

    • Maureen M. O’Brien, Michael J. Absalon, Thomas G. Gross, Kara M. Kelly

    Pages 251-301

12. Solid Tumors

    • Douglas S. Hawkins, Sarah Leary, Rochelle Bagatell, Melinda Merchant, Isabelle Aerts

    Pages 303-349

13. Future Directions

    • Franklin O. Smith, Judy M. Racadio, Gregory H. Reaman

    Pages 351-353

14. Back Matter

    Pages 355-358

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This book is a comprehensive and up-to-date compendium on all aspects of blood and marrow transplantation in children. After an introductory chapter describing the history of pediatric blood and marrow transplantation, subsequent chapters discuss pediatric-specific aspects of transplantation, including stem cell sources suitable for transplantation, preparative regimens, graft-versus-host disease, complications related to transplantation, and late effects. The role of blood and marrow transplantation in various specific pediatric diseases is then examined, and the closing chapter considers future directions. The authors are all internationally recognized experts and offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric diseases that are treatable with blood and marrow transplantation and will prove invaluable to specialists, generalists, and trainees alike.

• Bone marrow transplantation
• Hematopoietic stem cell transplantation
• Pediatrics
• Stem cell transplantation

• University of Cincinnati, Cincinnati, USA

  Franklin O. Smith

• George Washington University, Washington, USA

  Gregory H. Reaman

• Division of Hematology/Oncology, Dept. of Internal Medicine, University of Cincinnati College of Medicine, Madeira, USA

  Judy M. Racadio

Franklin Oscar Smith, III, gained his MD from the University of South Carolina School of Medicine, Columbia in 1984, having previously obtained a B.S. in Chemistry, cum laude, from Wofford College, Spartanburg, South Carolina. Professor Smith served as the Director of the Pediatric Stem Cell Transplantation Program at Riley Hospital for Children at the Indiana University School of Medicine from 1997 until 2001 when he appointed as the Director of the Division of Hematology/Oncology at Cincinnati Children’s Hospital Medical, serving in this role until 2010.  Since 2001 he has been Marjory J. Johnson Endowed Chair in Pediatric Hematology/Oncology and Professor of Pediatrics, with Tenure, at the Cincinnati Children’s Hospital Medical Center, University of Cincinnati.  He is also currently Interim Director of the Bone Marrow Transplantation Program and Associate Director of the Hematology/Oncology Fellowship Training Program in the Department of Internal Medicine, University of CincinnatiCollege of Medicine. He has been the recipient of many awards and honors, including a Distinguished Physician Alumni Award from the University of South Carolina School of Medicine, Alpha Omega Alpha membership, a Distinguished Service Award from the Children’s Oncology Group, the Amanda Toll Endowed Lectureship, and the Ronald Chard Endowed Lectureship. Professor Smith was the Vice-Chair of the Children’s Oncology Group, was a member of the Board of Directors of the Foundation for the Accreditation of Cellular Therapy as a member of the Medical and Scientific Affairs Committee of the Leukemia and Lymphoma Society. He has served on many National Institutes of Health and Food and Drug Administration ad hoc committees. Professor Smith has served on the editorial boards of several journals, including the British Journal of Haematology. He has authored or co-authored more than 100 peer-reviewed articles and reviews, many book chapters, editorials, and commentaries and a recent textbook on pediatric leukemia.   

Gregory H. Reaman, M.D., is currently Associate Director of the Office of Oncology Drug Products at the U.S. Food and Drug Administration's Center for Drug Evaluation and Research. In 2011, he completed 2 five year terms as the Chair of the Children’s Oncology Group (COG) since its inception in 2000 resulting from the merger of four legacy pediatric cancer research organizations . The COG is the largest pediatric cancer research organization in the world and is comprised of over 200 member institutions  throughout North America, Australia, and New Zealand , dedicated to clinical, translational, and epidemiology research in childhood cancer. Dr. Reaman is a Professor of Pediatrics at The George Washington University School of Medicine and Health Sciences and a member of the Division of Hematology-Oncology at the Children’s National Medical Center in Washington, D.C., which he directed for nearly 18 years, and Executive Director Emeritus of the Center for Cancer and Blood Disorders. Dr. Reaman serves or has served on the Editorial Boards of Leukemia, Journal of Clinical Oncology, Journal of Pediatric Hematology/Oncology, Pediatric Blood and Cancer, The Oncologist, Cancer, and Physicians Data Query (PDQ), National Cancer Institute as well as the ASCO Cancer Foundation’s www.cancer.net. He has served as an Associate Editor of Cancer and Leukemia and Lymphoma. Previously, he served on the Board of Directors of the American Cancer Society and chaired its Task Force on Children and Cancer. Dr. Reaman served on the Board of Directors of the American Society of Clinical Oncology and has served on the ASCO Patient Education,  Education and Program,  Grant Selection ,  the Cancer Research and Survivorship Committees  and was the Chair of the ASCO Membership Committee. Also, he was a member of the Food and Drug Administration’s Oncologic Drugs Advisory Committee and  was a long-standing  member of its Pediatric Subcommittee. He was a member of the NIH Roadmap Working Group. Additionally, he is a member of the Alliance for Childhood Cancer, a member of the Data Safety Monitoring Board of the National Cancer Institute’s Clinical Oncology Program, and a member of the NCI’s Translational Research Working Group. He is the author of more than  300  peer-reviewed manuscripts resulting from long-standing interests in acute leukemia biology and treatment and development of new drugs for pediatric cancer.

Judy M. Racadio is a former Emergency Medicine physician who currently performs medical writing and editing for various academic medical, private medical, and corporate departments.  She received her B.S. in 1988 from Xavier University in Cincinnati, Ohio (magna cum laude) and her M.D. in 1992 from the University of Cincinnati (alpha omega alpha).  After completing her Emergency Medicine residency, Dr. Racadio spent 6 years as an Assistant Professor of Emergency Medicine at the University of Cincinnati.  Since leaving clinical medicine, she has provided editorial assistance for a textbook on pediatric leukemia and a textbook on pediatric radiology. She has also co-authored or provided editorial assistance for more than 35 peer-reviewed publications and book chapters.   

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