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  • Book
  • © 2013

Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

  • A comprehensive review of the available information on RSV
  • Provides a better understanding of RSV as prerequisite for the development of effective vaccines
  • Written by leading experts in their respective fields
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 372)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xi
  2. Virology, Pathogenesis, and Clinical and Epidemiological Features of Disease

    1. Front Matter

      Pages 1-1
    2. Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease

      • Peter L. Collins, Rachel Fearns, Barney S. Graham
      Pages 3-38
    3. Clinical and Epidemiologic Features of Respiratory Syncytial Virus

      • Caroline B. Hall, Eric A. F. Simőes, Larry J. Anderson
      Pages 39-57
    4. Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins

      • Jason S. McLellan, William C. Ray, Mark E. Peeples
      Pages 83-104
    5. Respiratory Syncytial Virus and Reactive Airway Disease

      • Matthew T. Lotz, Martin L. Moore, R. Stokes Peebles Jr.
      Pages 105-118
  3. Host Response to Infection and Genetics of Disease

    1. Front Matter

      Pages 119-119
    2. Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches

      • Eun Hwa Choi, Hoan Jong Lee, Stephen J. Chanock
      Pages 121-137
    3. Innate Immune Responses to Respiratory Syncytial Virus Infection

      • Sumanta Mukherjee, Nicholas W. Lukacs
      Pages 139-154
    4. The Adaptive Immune Response to Respiratory Syncytial Virus

      • Steven M. Varga, Thomas J. Braciale
      Pages 155-171
    5. Host Gene Expression and Respiratory Syncytial Virus Infection

      • Ralph A. Tripp, Asuncion Mejias, Octavio Ramilo
      Pages 193-209
    6. Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus

      • Allison M. W. Malloy, Ann R. Falsey, Tracy J. Ruckwardt
      Pages 211-231
  4. Vaccine Platforms and Treatment Options

    1. Front Matter

      Pages 233-233
    2. Respiratory Syncytial Virus Disease: Prevention and Treatment

      • Helen Y. Chu, Janet A. Englund
      Pages 235-258
    3. Live-Attenuated Respiratory Syncytial Virus Vaccines

      • Ruth A. Karron, Ursula J. Buchholz, Peter L. Collins
      Pages 259-284
    4. Gene-Based Vaccine Approaches for Respiratory Syncytial Virus

      • Rebecca J. Loomis, Philip R. Johnson
      Pages 307-324
  5. Animal and Tissue Culture Models of Infection

    1. Front Matter

      Pages 325-325

About this book

Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

Reviews

From the reviews:

“I enjoyed the book: as an immunologist who has spent 10 years working on RSV there were a number of novel insights and it was nice to see it all in one place. … I will be recommending it to PhD students and Postdocs starting out on RSV research … . also recommend it to people who have been working with RSV for a while to dip in and out of to fill any gaps in the general knowledge.” (John Tregoning, Immunology News, May, 2014)

Editors and Affiliations

  • Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, USA

    Larry J. Anderson

  • Vaccine Research Center, NIH Natl. Inst. of Allergy & Infect. Dis., Bethesda, USA

    Barney S. Graham

Bibliographic Information

  • Book Title: Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

  • Editors: Larry J. Anderson, Barney S. Graham

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-38919-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2013

  • Hardcover ISBN: 978-3-642-38918-4Published: 07 January 2014

  • Softcover ISBN: 978-3-662-52155-7Published: 23 August 2016

  • eBook ISBN: 978-3-642-38919-1Published: 20 December 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 409

  • Number of Illustrations: 16 b/w illustrations, 22 illustrations in colour

  • Topics: Virology, Vaccine, Infectious Diseases, Pneumology/Respiratory System, Pediatrics

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access