Epigenetic Therapy of Cancer

1. Front Matter

   Pages i-x

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2. The Fundamental Role of Epigenetic Regulation in Normal and Disturbed Cell Growth, Differentiation, and Stemness

   • Manuel Rodríguez-Paredes, Manel Esteller

   Pages 1-41

3. Mouse Models to Study DNA Methylation in Cancer Research

   • Irina Savelyeva, Frank Rosenbauer

   Pages 43-66

4. Epigenetic Regulation of Normal Hematopoietic Development

   • Pratima Chaurasia, Dmitriy Berenzon, Ronald Hoffman

   Pages 67-87

5. Epigenetic Regulation of Globin Genes and Disturbances in Hemoglobinopathies

   • Yogen Saunthararajah, Donald Lavelle, Joseph DeSimone

   Pages 89-106

6. DNA Methylation Abnormalities in Hematopoietic Disorders: Biological Significance and Methodological Approaches

   • Rainer Claus, Maximilian Schmutz, Gabriele Greve, Lars Bullinger

   Pages 107-120

7. Epigenetic Modifications Mediated by the AML1/ETO and MLL Leukemia Fusion Proteins

   • Jesús Duque-Afonso, Michael Lübbert, Michael L. Cleary

   Pages 121-144

8. Treatment of Hematologic Malignancies with DNA Hypomethylating Agents

   • Michael Daskalakis, Tina E. Joeckel, Michael Lübbert, A. Kuendgen

   Pages 145-170

9. Pharmacodynamic Responses to DNA Methyltransferase Inhibition

   • Elizabeth Griffiths, Richard L. Momparler, Adam R. Karpf

   Pages 171-188

10. Histone Methyltransferases: Opportunities in Cancer Drug Discovery

    • Richard Chesworth, Tim J. Wigle, Kevin W. Kuntz, Jesse J. Smith, Victoria M. Richon

    Pages 189-226

11. Histone Deacetylase (HDAC) Inhibitors in Recent Clinical Trials for Cancer Therapy

    • Kristina Keller, Manfred Jung

    Pages 227-255

12. Clinical Implications of Epigenetic Alterations in Lung Cancer

    • David S. Schrump

    Pages 257-282

13. Epigenetic Disturbances in Colorectal Cancer

    • Sarah Derks, Manon van Engeland

    Pages 283-298

14. Epigenetic Therapies in Solid Tumours: From Preclinical Models to Clinical Trial Results

    • Robert Brown, Juliane Steinmann, Janet Graham, Ros Glasspool

    Pages 299-317

15. Back Matter

    Pages 319-325

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The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.

• Carcinoma
• Chromatin
• DNA Methylation
• Histone Organisation
• Myelodysplasia
• gene therapy

From the reviews:

“This new book covers the timely topic of epigenetic therapy. … The combination of articles describing the basic science framework of epigenetics and the detailed summaries of clinical trials with epigenetic drugs is attractive for a wide readership, ranging from medical students to scientists who are interested in translational studies to clinicians who work for the direct benefit of cancer patients. … This high-quality book is an excellent overview of the current success and future promise of epigenetic therapy.” (Gerd Pfeifer, Doody’s Book Reviews, May, 2014)

• Department of Hematology/Oncology, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany

  Michael Lübbert

• Norris Comprehensive Cancer Center Urologic Cancer Res. Lab., University of Southern California Dept. Biochemistry & Molecular Biology, Los Angeles, USA

  Peter A. Jones

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