Overview
- Latest research on Sialo-Xenoantigenic Glycobiology
- Focuses on carbohydrate antigens including sialic acids as xenoantigenic determinant in human
- Written by leading experts in the fiel
Part of the book series: Sungkyunkwan University Outstanding Research (SKKU, volume 1)
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Table of contents (5 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.
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Authors and Affiliations
Bibliographic Information
Book Title: Sialo-Xenoantigenic Glycobiology
Book Subtitle: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation
Authors: Kwon-Ho Song, Cheorl-Ho Kim
Series Title: Sungkyunkwan University Outstanding Research
DOI: https://doi.org/10.1007/978-3-642-34094-9
Publisher: Springer Berlin, Heidelberg
eBook Packages: Engineering, Engineering (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2013
Hardcover ISBN: 978-3-642-34093-2Published: 02 November 2012
Softcover ISBN: 978-3-642-43443-3Published: 14 December 2014
eBook ISBN: 978-3-642-34094-9Published: 02 November 2012
Series ISSN: 2195-3546
Series E-ISSN: 2195-3554
Edition Number: 1
Number of Pages: XVI, 64
Topics: Biomedical Engineering and Bioengineering, Molecular Medicine, Human Genetics, Medical Biochemistry, Biochemistry, general