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Novel Synthetic Chemistry of Ureas and Amides

  • Book
  • © 2013

Overview

Authors:
  1. Marc Hutchby

    1. , Thomas Graham House, Royal Society of Chemistry, Cambridge, United Kingdom

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  • Nominated by the University of Bristol as an outstanding PhD thesis
  • New method for breaking urea and amide bonds outlined
  • Far reaching consequences for the study of biological protein manipulation
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Introduction

    • Marc Hutchby
    Pages 1-35

  3. Pd(II) Catalysed Aminocarbonylation of Alkenes

    • Marc Hutchby
    Pages 37-44

  4. Carbonylation of Aryl Ureas

    • Marc Hutchby
    Pages 45-55

  5. Urea Hydrolysis

    • Marc Hutchby
    Pages 57-70

  6. Amide Hydrolysis

    • Marc Hutchby
    Pages 71-88

  7. Conclusions and Future Work

    • Marc Hutchby
    Pages 89-94

  8. Experimental

    • Marc Hutchby
    Pages 95-160

  9. Back Matter

    Pages 161-166
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Keywords

About this book

In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.

Authors and Affiliations

  • , Thomas Graham House, Royal Society of Chemistry, Cambridge, United Kingdom

    Marc Hutchby

Bibliographic Information

  • Book Title: Novel Synthetic Chemistry of Ureas and Amides

  • Authors: Marc Hutchby

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-642-32051-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-32050-7Published: 30 August 2012

  • Softcover ISBN: 978-3-642-44890-4Published: 20 September 2014

  • eBook ISBN: 978-3-642-32051-4Published: 30 August 2012

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XVIII, 166

  • Topics: Organic Chemistry, Catalysis, Protein Science

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