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Sex and Gender Differences in Pharmacology

  • Book
  • © 2012

Overview

Editors:
  1. Vera Regitz-Zagrosek

    1. Institute of Gender in Medicine (GiM), Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need
  • Connection to large database on sex differences in drug effects
  • Clear key note messages by international experts
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 214)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-ix
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  2. Sex Differences in Mechanisms of Disease

    1. Front Matter

      Pages 1-1
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  3. Sex differences in mechanisms of disease

    1. Sex and Gender Differences in Clinical Medicine

      • Vera Regitz-Zagrosek, Ute Seeland
      Pages 3-22

    2. Sex Differences in Animal Models for Cardiovascular Diseases and the Role of Estrogen

      • S. Mahmoodzadeh, D. Fliegner, E. Dworatzek
      Pages 23-48

    3. Sex Differences at Cellular Level: “Cells Have a Sex”

      • Elisabetta Straface, Lucrezia Gambardella, Marta Brandani, Walter Malorni
      Pages 49-65

    4. What a Difference an X or Y Makes: Sex Chromosomes, Gene Dose, and Epigenetics in Sexual Differentiation

      • Arthur P. Arnold, Xuqi Chen, Yuichiro Itoh
      Pages 67-88

  4. Sex Differences in Pharmacokinetics, in Drug Development and Use

    1. Front Matter

      Pages 89-89
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  5. Sex differences in pharmaco¬kinetics, in drug development and use.

    1. Sex Differences in Drug Effects: Interaction with Sex Hormones in Adult Life

      • Ilaria Spoletini, Cristiana Vitale, Walter Malorni, Giuseppe M C Rosano
      Pages 91-105

    2. Sex and Gender in Adverse Drug Events, Addiction, and Placebo

      • Flavia Franconi, Ilaria Campesi, Stefano Occhioni, Paola Antonini, Michael F. Murphy
      Pages 107-126

    3. Considerations of Sex and Gender Differences in Preclinical and Clinical Trials

      • Limor Raz, Virginia M. Miller
      Pages 127-147

    4. “Gender-Specific Drug Prescription in Germany” Results from Prescriptions Analyses

      • Gerd Glaeske, Cornelia Gerdau-Heitmann, Friederike Höfel, Christel Schicktanz
      Pages 149-167

    5. Gender and Polypharmacotherapy in the Elderly: A Clinical Challenge

      • Christina Hofer-Dückelmann
      Pages 169-182

    6. Role of Physician Gender in Drug Therapy

      • I. Gouni-Berthold, H. K. Berthold
      Pages 183-208

  6. Sex Differences in Different Therapeutic Areas

    1. Front Matter

      Pages 209-209
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  7. Sex differences in different therapeutic areas

    1. Sex and Gender Differences in Cardiovascular Drug Therapy

      • Ute Seeland, Vera Regitz-Zagrosek
      Pages 211-236

    2. Sex and Gender Aspects in Antiarrhythmic Therapy

      • Junko Kurokawa, Masami Kodama, Tetsushi Furukawa, Colleen E. Clancy
      Pages 237-263

    3. Sex and Gender Aspects in Anesthetics and Pain Medication

      • Ilaria Campesi, Marco Fois, Flavia Franconi
      Pages 265-278

    4. Psychopharmacological Treatment of Mood and Anxiety Disorders During Pregnancy

      • Stephanie Krüger
      Pages 279-305

    5. Obesity and Diabetes

      • Alexandra Kautzky-Willer, Rosa Lemmens-Gruber
      Pages 307-340

    6. Adrenal Disorders

      • Alois Gessl, Rosa Lemmens-Gruber, Alexandra Kautzky-Willer
      Pages 341-359
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Keywords

About this book

This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Editors and Affiliations

  • Institute of Gender in Medicine (GiM), Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin Berlin, Berlin, Germany

    Vera Regitz-Zagrosek

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