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Prospects for Chemoprevention of Colorectal Neoplasia

Emerging Role of Anti-Inflammatory Drugs

  • Book
  • © 2013

Overview

Editors:
  1. Andrew T. Chan

    1. Massachusetts General Hospital, Gastrointestinal Unit, Harvard Medical School, Boston, USA

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  2. Elmar Detering

    1. BSP-GD-GMA-CVRM, Berlin, S101, 09, 140, Bayer Schering Pharma AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Examines in detail important aspects of the current status and future prospects for chemoprevention of colorectal tumors
  • Discusses the latest data from drug trials and their implications
  • Adopts a holistic perspective
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 191)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. An Emerging Role for Anti-inflammatory Agents for Chemoprevention

    • Andrew T. Chan, Elmar Detering
    Pages 1-5

  3. Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia

    • Dan A. Dixon, Fernando F. Blanco, Annalisa Bruno, Paola Patrignani
    Pages 7-37

  4. Mode of Action of Aspirin as a Chemopreventive Agent

    • Melania Dovizio, Annalisa Bruno, Stefania Tacconelli, Paola Patrignani
    Pages 39-65

  5. Coxibs: Pharmacology, Toxicity and Efficacy in Cancer Clinical Trials

    • Luis A. Garcia Rodriguez, Lucia Cea-Soriano, Stefania Tacconelli, Paola Patrignani
    Pages 67-93

  6. COX-2 Active Agents in the Chemoprevention of Colorectal Cancer

    • Sarah Kraus, Inna Naumov, Nadir Arber
    Pages 95-103

  7. New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention

    • Heather N. Tinsley, William E. Grizzle, Ashraf Abadi, Adam Keeton, Bing Zhu, Yaguang Xi et al.
    Pages 105-120

  8. Aspirin in Prevention of Sporadic Colorectal Cancer: Current Clinical Evidence and Overall Balance of Risks and Benefits

    • Peter M. Rothwell
    Pages 121-142

  9. Nutritional Agents with Anti-lnflammatory Properties in Chemoprevention of Colorectal Neoplasia

    • Mark A. Hull
    Pages 143-156

  10. Genetics, Inheritance and Strategies for Prevention in Populations at High Risk of Colorectal Cancer (CRC)

    • John Burn, John Mathers, D. Tim Bishop
    Pages 157-183
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Keywords

About this book

The prevention of colorectal cancer is a subject of increasing medical importance, and there have been a number of promising recent developments. This book examines in detail important aspects of the current status and future prospects for chemoprevention of colorectal tumors. Research into the mechanisms that lead from early colorectal adenoma to colorectal cancer is discussed. The role and modes of action of available drugs such as celecoxib and sulindac are described, and recent data from aspirin trials are analyzed. In addition, the possible impact of nutritional agents with anti-inflammatory properties is considered, and strategies applicable in those with a high level of genetic risk are evaluated. An important feature of the book is its holistic perspective, making it relevant for gastroenterologists, internists, general practitioners, oncologists, colorectal and gastroenterological surgeons, and public health practitioners.

Reviews

From the reviews:

“Part of the Recent Results in Cancer Research series, this multiauthored book examines the emerging role of anti-inflammatory drugs as chemoprevention for colorectal neoplasia. … The authors wish to provide a multidisciplinary perspective on CRC chemoprevention. … As such, the book will appeal more to basic science researchers in this area.” (Willem J. de Villiers, Doody’s Review Service, November, 2012)

Editors and Affiliations

  • Massachusetts General Hospital, Gastrointestinal Unit, Harvard Medical School, Boston, USA

    Andrew T. Chan

  • BSP-GD-GMA-CVRM, Berlin, S101, 09, 140, Bayer Schering Pharma AG, Berlin, Germany

    Elmar Detering

Bibliographic Information

  • Book Title: Prospects for Chemoprevention of Colorectal Neoplasia

  • Book Subtitle: Emerging Role of Anti-Inflammatory Drugs

  • Editors: Andrew T. Chan, Elmar Detering

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-30331-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-30330-2Published: 15 August 2012

  • Softcover ISBN: 978-3-642-43447-1Published: 20 September 2014

  • eBook ISBN: 978-3-642-30331-9Published: 15 August 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: VIII, 184

  • Topics: Oncology, Gastroenterology, Internal Medicine, Cardiology, Colorectal Surgery

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