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Antibiotic Resistance

  • Book
  • © 2012

Overview

Editors:
  1. Anthony R.M. Coates

    1. , Div of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom

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  • This book provides views about antibiotic resistance from world experts in the field
  • The book has constructive ways in which to combat resistance,such as combinations of antibiotics, and targeting non-multiplying bacteria
  • It provides an outline of the challenges of the future, namely the need for a rebirth of the golden age of antibiotics in the mid-20th Century when 20 new classes of antibiotics reached the market

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 211)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. Introduction to Antibiotic Resistance

    • Richard Bax, David Griffin
    Pages 1-12

  3. The Origins of Antibiotic Resistance

    • Gerard D. Wright
    Pages 13-30

  4. Surveillance Programmes and Antibiotic Resistance: Worldwide and Regional Monitoring of Antibiotic Resistance Trends

    • Stephen Hawser
    Pages 31-43

  5. Current and Future Challenges in the Development of Antimicrobial Agents

    • Robert P. Rennie
    Pages 45-65

  6. The Role of the Outer Membrane of Gram-negative Bacteria in Antibiotic Resistance: Ajax’ Shield or Achilles’ Heel?

    • Malcolm G. P. Page
    Pages 67-86

  7. Prevention of Drug Resistance by Combined Drug Treatment of Tuberculosis

    • Denis A. Mitchison
    Pages 87-98

  8. Nonmultiplying Bacteria are Profoundly Tolerant to Antibiotics

    • Yanmin Hu, Anthony Coates
    Pages 99-119

  9. Persister Cells: Molecular Mechanisms Related to Antibiotic Tolerance

    • Kim Lewis
    Pages 121-133

  10. Antimicrobial Textiles

    • J. Vaun McArthur, R. C. Tuckfield, C. Baker-Austin
    Pages 135-152

  11. Efflux: How Bacteria Use Pumps to Control Their Microenvironment

    • E. David G. McIntosh
    Pages 153-166

  12. Antibiotics in Phase II and III Clinical Trials

    • Anthony R. M. Coates, Gerry Halls
    Pages 167-183

  13. Back Matter

    Pages 185-190
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Keywords

About this book

This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

Editors and Affiliations

  • , Div of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom

    Anthony R.M. Coates

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