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RNA Metabolism in Trypanosomes

  • Book
  • © 2012

Overview

Editors:
  1. Albrecht Bindereif

    1. , Department of Biology and Chemistry, Justus Liebig University of Giessen, Giessen, Germany

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  • Presents the latest findings on RNA metabolism
  • In depth analysis of trypanosome transcription mechanism
  • Written by experts in the field

Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 28)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
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  2. RNA Polymerases and Transcription Factors of Trypanosomes

    • Arthur Günzl
    Pages 1-27

  3. SL RNA Biogenesis in Kinetoplastids: A Long and Winding Road

    • Nancy R. Sturm, Jesse R. Zamudio, David A. Campbell
    Pages 29-47

  4. Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation

    • Christian Preußer, Nicolas Jaé, Arthur Günzl, Albrecht Bindereif
    Pages 49-77

  5. mRNA Turnover in Trypanosomes

    • Christine Clayton
    Pages 79-97

  6. tRNA Biogenesis and Processing

    • Jessica L. Spears, Mary Anne T. Rubio, Paul J. Sample, Juan D. Alfonzo
    Pages 99-121

  7. rRNA Biogenesis in Trypanosomes

    • Shulamit Michaeli
    Pages 123-148

  8. RNA Editing in African Trypanosomes: A U-ser’s G-U-ide

    • H. Ulrich Göringer
    Pages 149-165

  9. The RNA Interference Pathway in Trypanosoma brucei

    • Elisabetta Ullu, Nikolay G. Kolev, Rebecca L. Barnes, Christian Tschudi
    Pages 167-185

  10. Translation in Trypanosomatids

    • Michal Shapira, Alexandra Zinoviev
    Pages 187-214

  11. Mitochondrial Translation in Trypanosomatids

    • Dmitri A. Maslov, Rajendra K. Agrawal
    Pages 215-236

  12. RNA-Seq Analysis of the Transcriptome of Trypanosoma brucei

    • Jan Mani, Kapila Gunasekera, Isabel Roditi
    Pages 237-265

  13. Back Matter

    Pages 267-271
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Keywords

About this book

Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.

Editors and Affiliations

  • , Department of Biology and Chemistry, Justus Liebig University of Giessen, Giessen, Germany

    Albrecht Bindereif

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