Overview
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 355)
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Table of contents (11 chapters)
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Front Matter
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Back Matter
Keywords
- Mitogen Activated Protein Kinase (MAPK)
- Raf kinases
- biomarkers
- chemical library
- clinical trial design
- drug development
- drug efficacy
- epigenetics
- gastrointestinal stromal tumor (GIST)
- genetically engineered mouse models (GEMMs)
- glioblastoma
- lung adenocarcinoma
- lung cancer
- melanoma
- myeloproliferative neoplasms
- small molecules
About this book
Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as “chemotherapy” and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates.
This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editors invited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authors hope these lessons will be instructive for the novice as well as the expert.
Editors and Affiliations
Bibliographic Information
Book Title: Therapeutic Kinase Inhibitors
Editors: Ingo K. Mellinghoff, Charles L. Sawyers
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-642-28296-6
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2012
Hardcover ISBN: 978-3-642-28295-9Published: 22 March 2012
Softcover ISBN: 978-3-642-44580-4Published: 13 April 2014
eBook ISBN: 978-3-642-28296-6Published: 27 November 2012
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: X, 234
Topics: Cancer Research