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Drug Discovery in Africa

Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs

  • Gives professionals and students a tool needed to facilitate drug discovery in Africa
  • Brings together for the first time challenges and opportunities, as well as a collection of strategies and techniques that need to be considered when developing new drugs in an African setting
  • Highlights the remarkable effort made so far in the area of drug discovery research by African scientists and scientists from other parts of the world working on African health problems
  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xx
  2. The National Cancer Institute and Natural Product-Based Drug Discovery in Africa

    • John A. Beutler, Gordon M. Cragg, David J. Newman
    Pages 29-52
  3. Tuberculosis Drug Discovery: Target Identification and Validation

    • Digby F. Warner, Valerie Mizrahi
    Pages 53-84
  4. Application of In Silico, In Vitro and In Vivo ADMET/PK Platforms in Drug Discovery

    • Collen Masimirembwa, Roslyn Thelingwani
    Pages 151-191
  5. Marine Bioprospecting in Southern Africa

    • Michael T. Davies-Coleman, Suthananda N. Sunassee
    Pages 193-209
  6. “Now I Heal with Pride”—The Application of Screens-to-Nature Technology to Indigenous Knowledge Systems Research in Botswana: Implications for Drug Discovery

    • Kerstin Andrae-Marobela, Aku N. Ntumy, Masego Mokobela, Mthandazo Dube, Angelina Sosome, Mbaki Muzila et al.
    Pages 239-264
  7. Innovative Approaches to Exploiting Traditional Medicines in Malaria

    • Philippe Rasoanaivo, Solofoniaina Razafimahefa
    Pages 265-292
  8. Tackling the Problem of Antimalarial Resistance

    • John Okombo, Leah Mwai, Alexis Nzila
    Pages 301-324
  9. Random and Rational Approaches to HIV Drug Discovery in Africa

    • R. Hewer, F. H. Kriel, J. Coates
    Pages 325-354
  10. Nanomedicine in the Development of Drugs for Poverty-Related Diseases

    • Rose Hayeshi, Boitumelo Semete, Lonji Kalombo, Lebogang Katata, Yolandy Lemmer, Paula Melariri et al.
    Pages 407-429
  11. Back Matter

    Pages 431-438

About this book

Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

Editors and Affiliations

  • , Dept. of Chemistry, University of Cape Town, Rondebosch, South Africa

    Kelly Chibale

  • , Department of Chemistry, Rhodes University, Grahamstown, South Africa

    Mike Davies-Coleman

  • and Technology, African Institute of Biomedical Science, Harare, Zimbabwe

    Collen Masimirembwa

Bibliographic Information

  • Book Title: Drug Discovery in Africa

  • Book Subtitle: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs

  • Editors: Kelly Chibale, Mike Davies-Coleman, Collen Masimirembwa

  • DOI: https://doi.org/10.1007/978-3-642-28175-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2012

  • Hardcover ISBN: 978-3-642-28174-7Published: 08 August 2012

  • Softcover ISBN: 978-3-642-43022-0Published: 20 September 2014

  • eBook ISBN: 978-3-642-28175-4Published: 09 August 2012

  • Edition Number: 1

  • Number of Pages: XX, 440

  • Topics: Medicinal Chemistry, Organic Chemistry, Pharmacy, Medical Biochemistry

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access