Theranostics, Gallium-68, and Other Radionuclides

1. Front Matter

   Pages i-xviii

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2. Generators

   1. Front Matter

      Pages 1-1

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   2. 68Ge/68Ga Generators: Past, Present, and Future

      • F. Rösch

      Pages 3-16

   3. Overview and Perspectives on Automation Strategies in 68Ga Radiopharmaceutical Preparations

      • Stefano Boschi, Claudio Malizia, Filippo Lodi

      Pages 17-31

   4. Post-Processing via Cation Exchange Cartridges: Versatile Options

      • F. Rösch

      Pages 33-42

   5. 68Ga Generator Integrated System: Elution–Purification–Concentration Integration

      • Van So Le

      Pages 43-75

   6. Purification and Labeling Strategies for 68Ga from 68Ge/68Ga Generator Eluate

      • Dirk Mueller, Ingo Klette, Richard P. Baum

      Pages 77-87

   7. 67Ga and 68Ga Purification Studies: Preliminary Results

      • R. F. Costa, M. F. Barboza, J. A. Osso Jr

      Pages 89-97

3. Radiochemistry and Radiopharmacy

   1. Front Matter

      Pages 99-99

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   2. The Diversity of 68Ga-Based Imaging Agents

      • Irina Velikyan

      Pages 101-131

   3. Nanoparticles and Phage Display Selected Peptides for Imaging and Therapy of Cancer

      • Cathy S. Cutler, Nripen Chanda, Ravi Shukla, Nebiat Sisay, Melchor Cantorias, Ajit Zambre et al.

      Pages 133-147

   4. “Click”-Cyclized 68Ga-Labeled Peptides for Molecular Imaging and Therapy: Synthesis and Preliminary In Vitro and In Vivo Evaluation in a Melanoma Model System

      • Molly E. Martin, M. Sue O’Dorisio, Whitney M. Leverich, Kyle C. Kloepping, Susan A. Walsh, Michael K. Schultz

      Pages 149-175

   5. Early Experience with 68Ga-DOTATATE Preparation

      • Maung Maung Saw

      Pages 177-188

   6. 68Ga-Radiopharmaceuticals for PET Imaging of Infection and Inflammation

      • Vijay Kumar, Dilip K. Boddeti

      Pages 189-219

   7. 68Ga-Labeled Bombesin Analogs for Receptor-Mediated Imaging

      • Raunak Varshney, Puja P. Hazari, P. Fernandez, J. Schulz, M. Allard, Anil K. Mishra

      Pages 221-256

   8. A Novel 68Ga-Labeled Pteroic Acid-Based PET Tracer for Tumor Imaging via the Folate Receptor

      • Berit Kühle, Cristina Müller, Tobias L. Ross

      Pages 257-267

   9. Measurement of Protein Synthesis: In Vitro Comparison of 68Ga-DOTA-Puromycin, [3H]Tyrosine, and 2-Fluoro-[3H]tyrosine

      • Sebastian Eigner, Denis R. Beckford Vera, Marco Fellner, Natalia S. Loktionova, Markus Piel, Frantisek Melichar et al.

      Pages 269-283

   10. Hypoxia Imaging Agents Labeled with Positron Emitters

       • Lathika Hoigebazar, Jae Min Jeong

       Pages 285-299

   11. 177Lu/90Y Intermediate-Affinity Monoclonal Antibodies Targeting EGFR and HER2/c-neu: Preparation and Preclinical Evaluation

       • Denis R. Beckford Vera, Sebastian Eigner, Katerina Eigner Henke, Rene Leyva Montaña, Frantisek Melichar, Milos Beran

       Pages 301-317

4. Molecular Imaging Using 68Ga labeled Tracers

   1. Front Matter

      Pages 319-319

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This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics – the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

• Gallium-68
• Neuroendocrine tumors
• PET radiopharmaceuticals
• Radionuclides
• Theranostics
• Radiaton Oncology

From the reviews:

“The general themes of this book (theranostics and peptide receptor–targeted radiotherapy) derive from evolving successes in the use of generator-produced ⁶⁸Ga for molecular imaging of disease. … This book is an excellent resource for investigators interested in gaining a detailed understanding of the state of the art in ⁶⁸Ga and peptide receptor radionuclide therapy–based theranostics for preclinical and emerging clinical applications.” (Michael K. Schultz, The Journal of Nuclear Medicine, Vol. 54 (4), April, 2013)

• , THERANOSTICS Center for Molecular,, ENETS Center of Excellence, Bad Berka, Germany

  Richard P. Baum

• Inst. Kernchemie, Universität Mainz, Mainz, Germany

  Frank Rösch

Policies and ethics