Treatment of Dry Skin Syndrome

1. Front Matter

   Pages i-xxxvii

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2. The Marketplace and Treatment Aspects

   1. Front Matter

      Pages 1-1

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3. THE MARKETPLACE AND TREATMENT ASPECTS

   1. Moisturizers as Cosmetics, Medicines, or Medical Device? The Regulatory Demands in the European Union

      • Amy Sörensen, Peter Landvall, Marie Lodén

      Pages 3-16

   2. Design of Claims Support for Moisturizers

      • Judith K. Woodford

      Pages 17-25

   3. Educational Interventions for the Management of Children with Dry Skin

      • Steven J. Ersser, Noreen Heer Nicol

      Pages 27-39

   4. Dry Skin in Childhood and the Misery of Eczema and Its Treatments

      • Susan Lewis-Jones

      Pages 41-58

   5. Use of Moisturizers in Patients with Atopic Dermatitis

      • Kam Lun Ellis Hon, Alexander K. C. Leung

      Pages 59-73

4. Skin Essentials

   1. Front Matter

      Pages 75-75

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5. SKIN ESSENTIALS

   1. Sensory Systems of Epidermal Keratinocytes

      • Mitsuhiro Denda

      Pages 77-94

   2. Sensitive Skin: Intrinsic and Extrinsic Contributors

      • Miranda A. Farage, Michael K. Robinson

      Pages 95-109

   3. Electron Tomography of Skin

      • Lars Norlén

      Pages 111-117

   4. Filaggrin Gene Defects and Dry Skin Barrier Function

      • Martin Willy Meyer, Jacob P. Thyssen

      Pages 119-124

   5. Molecular Organization of the Lipid Matrix in Stratum Corneum and Its Relevance for the Protective Functions of Human Skin

      • Mila Boncheva

      Pages 125-147

   6. Desquamation: It Is Almost All About Proteases

      • Rainer Voegeli, Anthony V. Rawlings

      Pages 149-178

   7. Endogenous Retroviral-Like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization

      • Takeshi Matsui

      Pages 179-192

   8. Vernix Caseosa and Its Substitutes: Lipid Composition and Physicochemical Properties

      • Marty O. Visscher, Steven B. Hoath

      Pages 193-213

   9. The Role of Tight Junctions and Aquaporins in Skin Dryness

      • J. M. Brandner

      Pages 215-232

   10. Biomechanics of the Barrier Function of Human Stratum Corneum

       • Kemal Levi, Reinhold H. Dauskardt

       Pages 233-254

6. Dry Skin Disorders and Treatments

   1. Front Matter

      Pages 255-255

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7. DRY SKIN DISORDERS AND TREATMENTS

   1. Update on Atopic Eczema with Special Focus on Dryness and the Impact of Moisturizers

      • Eric Simpson

      Pages 257-267

Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.

• Barrier function
• Eczema
• Emollients
• Ingredients
• Skin biochemistry

• Eviderm Institute, Solna, Sweden

  Marie Lodén

• School of Medicine, Department Dermatology, University of California, San Francisco, San Francisco, USA

  Howard I. Maibach

Dr. Marie Lodén was appointed Associate Professor in Experimental Dermatology at Uppsala University in 2005 and is the founder and owner of the Eviderm Institute, Sweden, which is devoted to dermatological research and product development. Dr. Lodén previously conducted dermatological research on chemical warfare agents and worked on the development of topical treatments at pharmaceutical and cosmetics companies. Her major research interests are skin barrier function, contact dermatitis, skin care, biophysical measurements, and toxicology. She has edited previous books and published almost 100 original papers and reviews. Howard I. Maibach is Professor of Dermatology at the University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted much original research and written very extensively. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health.

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