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  • Book
  • © 2013

Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

  • A comprehensive review
  • Written by leading experts
  • Richly illustrated
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 369)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
  2. The Origin of Hepatitis C Virus

    • Peter Simmonds
    Pages 1-15
  3. Cell Culture Systems for Hepatitis C Virus

    • Eike Steinmann, Thomas Pietschmann
    Pages 17-48
  4. Animal Models for Hepatitis C

    • Eva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, Alexander Ploss
    Pages 49-86
  5. Hepatitis C Virus Entry

    • Mirjam B. Zeisel, Daniel J. Felmlee, Thomas F. Baumert
    Pages 87-112
  6. Hepatitis C Virus Proteins: From Structure to Function

    • Darius Moradpour, François Penin
    Pages 113-142
  7. Hepatitis C Virus RNA Translation

    • Michael Niepmann
    Pages 143-166
  8. Hepatitis C Virus RNA Replication

    • Volker Lohmann
    Pages 167-198
  9. Virion Assembly and Release

    • Brett D. Lindenbach
    Pages 199-218
  10. Innate Immune Responses to Hepatitis C Virus

    • John W. Schoggins, Charles M. Rice
    Pages 219-242
  11. Adaptive Immune Responses in Hepatitis C Virus Infection

    • Christoph Neumann-Haefelin, Robert Thimme
    Pages 243-262
  12. Liver Injury and Disease Pathogenesis in Chronic Hepatitis C

    • Daisuke Yamane, David R. McGivern, Takahiro Masaki, Stanley M. Lemon
    Pages 263-288
  13. Hepatitis C Virus-Specific Directly Acting Antiviral Drugs

    • Leen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, Raffaele De Francesco
    Pages 289-320
  14. Treatment of Chronic Hepatitis C: Current and Future

    • Jean-Michel Pawlotsky
    Pages 321-342
  15. Back Matter

    Pages 343-345

About this book

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Editors and Affiliations

  • Department for Infectious Diseases Molecular Virology, University of Heidelberg, Heidelberg, Germany

    Ralf Bartenschlager

Bibliographic Information

  • Book Title: Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

  • Editors: Ralf Bartenschlager

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-27340-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2013

  • Hardcover ISBN: 978-3-642-27339-1Published: 15 March 2013

  • Softcover ISBN: 978-3-642-42936-1Published: 09 April 2015

  • eBook ISBN: 978-3-642-27340-7Published: 12 March 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VIII, 346

  • Number of Illustrations: 14 b/w illustrations, 20 illustrations in colour

  • Topics: Virology, Immunology, Drug Resistance, Hepatology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access