Overview
- Nominated by University College Dublin as an outstanding PhD thesis
- Author describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4
- Description of an excellent route to a thiophene-containing LXA4 analogue
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (6 chapters)
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Front Matter
Keywords
About this book
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Authors and Affiliations
Bibliographic Information
Book Title: Heteroaromatic Lipoxin A4 Analogues
Book Subtitle: Synthesis and Biological Evaluation
Authors: Colm Duffy
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-642-24632-6
Publisher: Springer Berlin, Heidelberg
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2012
Hardcover ISBN: 978-3-642-24631-9Published: 05 January 2012
Softcover ISBN: 978-3-642-43892-9Published: 22 February 2014
eBook ISBN: 978-3-642-24632-6Published: 10 January 2012
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XXII, 130
Topics: Bioorganic Chemistry, Biochemistry, general, Medicinal Chemistry, Catalysis