Overview
- Nominated as an outstanding contribution by the University of Aberdeen
- Contains essential new results on the statistical mechanics and dynamics of macromolecular assembly
- Yields important conclusions and predictions for biological membranes
- Work done in close cooperations with biologists studying membrane proteins
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (5 chapters)
Keywords
About this book
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.
Authors and Affiliations
Bibliographic Information
Book Title: Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane
Authors: Ksenia Guseva
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-642-23988-5
Publisher: Springer Berlin, Heidelberg
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2012
Hardcover ISBN: 978-3-642-23987-8Published: 02 October 2011
Softcover ISBN: 978-3-642-26994-3Published: 29 November 2013
eBook ISBN: 978-3-642-23988-5Published: 01 October 2011
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XII, 80
Topics: Biological and Medical Physics, Biophysics, Membrane Biology, Complex Systems, Polymer Sciences, Statistical Physics and Dynamical Systems