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Modeling Fragile X Syndrome

  • Book
  • © 2012

Overview

Editors:
  1. Robert B. Denman

    1. New York State Institute for Basic Resea, Staten Island, USA

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  • Comprehensive overview on the molecular basis of fragile X syndrome
  • First book to cover all models used to investigate fragile X syndrome
  • Includes state-of-of the art approaches like epigenetics
  • Includes supplementary material: sn.pub/extras

Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 54)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xi
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  2. Ex Vivo Models

    1. Front Matter

      Pages 13-13
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    2. Introduction: Reminiscing on Models and Modeling

      • Robert B. Denman
      Pages 1-12

    3. Probing Astrocyte Function in Fragile X Syndrome

      • Shelley Jacobs, Connie Cheng, Laurie C. Doering
      Pages 15-31

    4. Neural Stem Cells

      • Maija Castrén
      Pages 33-40

    5. Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System

      • Theodore J. Price, Ohannes K. Melemedjian
      Pages 41-59

    6. The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome

      • Stefan Kindler, Hans-Jürgen Kreienkamp
      Pages 61-80

  3. Non-Mouse Eukaryote Models

    1. Front Matter

      Pages 81-81
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    2. Behavior in a Drosophila Model of Fragile X

      • Sean M. McBride, Aaron J. Bell, Thomas A. Jongens
      Pages 83-117

    3. Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome

      • Charles R. Tessier, Kendal Broadie
      Pages 119-156

    4. Fragile X Mental Retardation Protein and Stem Cells

      • Abrar Qurashi, Xuekun Li, Peng Jin
      Pages 157-164

    5. Manipulating the Fragile X Mental Retardation Proteins in the Frog

      • Marc-Etienne Huot, Nicolas Bisson, Thomas Moss, Edouard W. Khandjian
      Pages 165-179

    6. Exploring the Zebra Finch Taeniopygia guttata as a Novel Animal Model for the Speech–Language Deficit of Fragile X Syndrome

      • Claudia Winograd, Stephanie Ceman
      Pages 181-197

  4. Novel Mouse Models

    1. Front Matter

      Pages 199-199
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    2. Neuroendocrine Alterations in the Fragile X Mouse

      • Abdeslem El Idrissi, Xin Yan, William L’Amoreaux, W. Ted Brown, Carl Dobkin
      Pages 201-221

    3. Taking STEPs Forward to Understand Fragile X Syndrome

      • Susan M. Goebel-Goody, Paul J. Lombroso
      Pages 223-241

    4. Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease

      • Bojana Zupan, Miklos Toth
      Pages 243-253

    5. Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome

      • Michael R. Hunsaker, Gloria Arque, Robert F. Berman, Rob Willemsen, Renate K. Hukema
      Pages 255-269

  5. The Human Model

    1. Front Matter

      Pages 271-271
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    2. Clinical Aspects of the Fragile X Syndrome

      • W. Ted Brown
      Pages 273-279
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Keywords

About this book

Introduction.-Probing Astrocyte Function in Fragile X Syndrome.- Neural Stem Cells.- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System.– The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome.- Behavior in a Drosophila model of Fragile X.- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome.- Fragile X Mental Retardation Protein and Stem Cells.- Manipulating the Fragile X Mental Retardation Proteins in the Frog.- Exploring the Zebra finch Taeniopygia gutta as a Novel Animal Model for the Speech-language Deficit of Fragile X Syndrome.- Neuroendocrine Alterations in the Fragile X Mouse.- Taking STEPs forward to understanding Fragile X Syndrome.- Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease.- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome.- Clinical Aspects of the Fragile X Syndrome.- Fragile X Syndrome: A Psychiatric Perspective.- Fragile X Syndrome and Targeted Treatment Trials.- The Fragile X-associate Tremor Ataxia Syndrome.- Vignettes: Models in Absentia.

Editors and Affiliations

  • New York State Institute for Basic Resea, Staten Island, USA

    Robert B. Denman

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