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Histone Deacetylases: the Biology and Clinical Implication

  • Book
  • © 2011

Overview

Editors:
  1. Tso-Pang Yao

    1. , Department of Pharmacology, Duke University, Durham, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Edward Seto

    1. , Department of Molecular Oncology, H.Lee Moffitt Cancer Center & Research I, Tampa, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Will certainly serve as a reference to catalyze new collaborations between experts within the HDAC field
  • Written by leading authorities in the field
  • With numerous illustrations

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 206)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi
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  2. K-Acetylation and Its Enzymes: Overview and New Developments

    • Juliette Adjo Aka, Go-Woon Kim, Xiang-Jiao Yang
    Pages 1-12

  3. The Biology of HDAC in Cancer: The Nuclear and Epigenetic Components

    • Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayr, Christian Seiser
    Pages 13-37

  4. Deacetylation of Nonhistone Proteins by HDACs and the Implications in Cancer

    • Lirong Peng, Edward Seto
    Pages 39-56

  5. The Biology and Therapeutic Implications of HDACs in the Heart

    • Timothy A. McKinsey
    Pages 57-78

  6. HDACs in Skeletal Muscle Remodeling and Neuromuscular Disease

    • Bryan J. Simmons, Todd J. Cohen, Richard Bedlack, Tso-Pang Yao
    Pages 79-101

  7. Rationale for HDAC Inhibitor Therapy in Autoimmunity and Transplantation

    • Wayne W. Hancock
    Pages 103-123

  8. The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity

    • Akiko Satoh, Liana Stein, Shin Imai
    Pages 125-162

  9. Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation

    • David B. Lombard, Daniel X. Tishkoff, Jianjun Bao
    Pages 163-188

  10. Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance

    • Debra Toiber, Carlos Sebastian, Raul Mostoslavsky
    Pages 189-224

  11. Structural Biology of Human Metal-Dependent Histone Deacetylases

    • Matthieu Schapira
    Pages 225-240

  12. Sirtuin Modulators

    • Sumit S. Mahajan, Vid Leko, Julian A. Simon, Antonio Bedalov
    Pages 241-255

  13. Back Matter

    Pages 257-260
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Keywords

About this book

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Editors and Affiliations

  • , Department of Pharmacology, Duke University, Durham, USA

    Tso-Pang Yao

  • , Department of Molecular Oncology, H.Lee Moffitt Cancer Center & Research I, Tampa, USA

    Edward Seto

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