Life Sciences and Radiation

1. Front Matter

   Pages I-XIV

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2. Introductory Remarks: On the State of Radiation Research

   1. Introductory Remarks: On the State of Radiation Research

      • Jürgen Kiefer

      Pages 1-6

3. Cellular Responses, Genomic Stability

   1. Front Matter

      Pages 7-7

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   2. Cellular Responses to DNA Damage — a Personal Account

      • George Iliakis

      Pages 9-27

   3. Prospects for Research in Radiation Biology

      • Charles L. Limoli

      Pages 29-43

   4. Cellular and Molecular Aspects of the Anti-inflammatory Action of Low Dose Ionizing Irradiation

      • Peter M. Kern

      Pages 45-55

   5. The Network of Radiation Responses and Genomic Stability

      • Friederike Eckardt-Schupp, Simone Mörtl, Eberhard Fritz

      Pages 57-67

   6. Topological Factors in Radiation Biology

      • Anna A. Friedl

      Pages 69-77

4. Signalling

   1. Front Matter

      Pages 79-79

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   2. Molecular Radiation Biology — Perspectives for the Future

      • H. Peter Rodemann

      Pages 81-91

   3. P53 Stabilization and the Role of Radiation-Induced Signalling

      • Christine Blattner, Markus Winter, Roman Kulikov

      Pages 93-99

5. Cytogenetics

   1. Front Matter

      Pages 101-101

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   2. Molecular Genetic Mechanisms of Radiocarcinogenesis and Predictive Markers for Radioresistance in Tumors — Present Work and Future Perspectives —

      • Ludwig Hieber, Horst Zitzelsberger

      Pages 103-110

   3. FISH and CHIPs: Colorful Clues to Radiation-Induced Chromosomal Instability

      • Tanja Hardt, Karen Stout, Frank Guthermuth, Jürgen Kiefer, Thomas Haaf

      Pages 111-117

6. Carcinogenesis, Radiation Protection

   1. Front Matter

      Pages 119-119

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   2. Recombination and Radiation-Induced Cancer. Mechanisms and Genetic Testing

      • Jochen Dahm-Daphi, Petra Hubbe

      Pages 121-137

   3. UV-Radiation Biology as Part of Cancer Research

      • R. Greinert, E. W. Breitbart, B. Volkmer

      Pages 139-155

   4. Contribution of Radiation Research to Human Space Exploration: Approaches to mitigate Radiation Health Risk in Spaceflight

      • Marco Durante

      Pages 157-168

7. Repair

   1. Front Matter

      Pages 169-169

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   2. Radiation Damage and Human Cells: You have to know one to understand the other

      • Markus Löbrich

      Pages 171-177

Scope and ideas of the workshop The workshop which took place at the University of Giessen from Oct. 3 to Oct. 7, 2002 and whose proceedings are collected in this volume started from the idea to convene a number of scientists with the aim to outline their ”visions” for the future of radiation research on the basis of their expertise. As radiation research is a very wide field restrictions were unavoidable. It was decided to concentrate this time mainly on molecular and cellular biology because it was felt that here action is par-ticularly needed. This did not exclude contributions from neighbouring fields as may be seen from the table of contents. It was clearly not planned to have a c- prehensive account of the present scientif fic achievements but the results presented should only serve as a starting point for the discussion of future lines of research, with the emphasis on the ”outreach” to other parts of life sciences. If you are interested in the future ask the young – we attempted, therefore, to invite mainly younger colleagues (with a few exceptions) who had, however, already left their marks in the field. They were asked to describe what they felt is important in radiation research and may have significant influences on other branches of life sciences. They were given the task to demonstrate what is lost for science ”if we do no longer exist”.

• DNA
• FISH
• cells
• ionizing
• molecular biology
• positron emission tomography
• spaceflight
• tissue
• Radiaton Oncology

• Strahlenzentrum, Justus-Liebig-Universität Giessen, Giessen, Germany

  Jürgen Kiefer

Policies and ethics