Effect-Directed Analysis of Complex Environmental Contamination

1. Front Matter

   Pages i-xviii

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2. Early Evolution of the Toxicity Identification Evaluation Process: Contributions from the United States Environmental Protection Agency Effluent Testing Program

   • Gerald T. Ankley, James R. Hockett, Donald I. Mount, David R. Mount

   Pages 1-18

3. Recent Developments in Whole Sediment Toxicity Identification Evaluations: Innovations in Manipulations and Endpoints

   • Robert M. Burgess, Kay T. Ho, Adam D. Biales, Werner Brack

   Pages 19-40

4. Considerations for Incorporating Bioavailability in Effect-Directed Analysis and Toxicity Identification Evaluation

   • Werner Brack, Robert M. Burgess

   Pages 41-68

5. Diagnostic Tools for Effect-Directed Analysis of Mutagens, AhR Agonists, and Endocrine Disruptors

   • Gisela Umbuzeiro, Miroslav Machala, Jana Weiss

   Pages 69-82

6. Separation Techniques in Effect-Directed Analysis

   • Werner Brack, Nadin Ulrich, Mahmoud Bataineh

   Pages 83-118

7. Simultaneous Screening and Chemical Characterization of Bioactive Compounds Using LC-MS-Based Technologies (Affinity Chromatography)

   • Martin Giera, Hubertus Irth

   Pages 119-141

8. Advanced GC–MS and LC–MS Tools for Structure Elucidation in Effect-Directed Analysis

   • Pim E. G. Leonards, Rikke Brix, Damià Barceló, Marja Lamoree

   Pages 143-165

9. Computer Tools for Structure Elucidation in Effect-Directed Analysis

   • Emma Schymanski, Tobias Schulze, Jos Hermans, Werner Brack

   Pages 167-198

10. Effect-Directed Analysis of Mutagens in Ambient Airborne Particles

    • John L. Durant, Arthur L. Lafleur

    Pages 199-235

11. Effect-Directed Analysis of Endocrine Disruptors in Aquatic Ecosystems

    • Corine J. Houtman, Juliette Legler, Kevin Thomas

    Pages 237-265

12. Effects-Directed Studies of Pulp and Paper Mill Effluents

    • Mark Hewitt

    Pages 267-283

13. Effect-Directed Analysis of Ah-Receptor Mediated Toxicants, Mutagens, and Endocrine Disruptors in Sediments and Biota

    • Markus Hecker, John P. Giesy

    Pages 285-313

14. Ecological Relevance of Key Toxicants in Aquatic Systems

    • Mechthild Schmitt-Jansen, Peter C. von der Ohe, Stephanie Franz, Stefanie Rotter, Sergi Sabater, Dick de Zwart et al.

    Pages 315-339

15. Back Matter

    Pages 341-345

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Today more than 5 million chemicals are known and roughly 100,000 of them are frequently used, with both numbers rising. Many of these chemicals are ultimately released into the environment and may cause adverse effects to ecosystems and human health. Effect-directed analysis (EDA) is a promising tool for identifying predominant toxicants in complex, mostly environmental mixtures combining effect testing, fractionation and chemical analysis. In the present book leading experts in the field provide an overview of relevant approaches and tools used in EDA. This includes diagnostic biological tools, separation techniques and advanced analytical and computer tools for toxicant identification and structure elucidation. Examples of the successful application of EDA are discussed such as the identification of mutagens in airborne particles and sediments, of endocrine disruptors in aquatic ecosystems and of major toxicants in pulp and paper mill effluents. This book is a valuable, comprehensive and interdisciplinary source of information for environmental scientists and environmental agencies dealing with the analysis, monitoring and assessment of environmental contamination.

• carcinogens
• effect-directed analysis
• endocrine disruptors
• environmental toxicology
• mutagens
• toxicants

• for Environmental Research, Department of Effect-Directed Analysis, UFZ Helmholtz Centre, Leipzig, Germany

  Werner Brack

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