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  • Book
  • © 2011

Phosphodiesterases as Drug Targets

  • provides a summary of the major concepts related to the design and use of PDE inhibitors
  • describes exciting ideas and developments that are currently emerging in this dynamic and important field
  • written by leading authorities in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 204)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvii
  2. Phosphodiesterase Inhibitors: History of Pharmacology

    • Christian Schudt, Armin Hatzelmann, Rolf Beume, Hermann Tenor
    Pages 1-46
  3. Phosphodiesterase Inhibitors: Factors That Influence Potency, Selectivity, and Action

    • Sharron H. Francis, Miles D. Houslay, Marco Conti
    Pages 47-84
  4. Pharmacology, Clinical Efficacy, and Tolerability of Phosphodiesterase-4 Inhibitors: Impact of Human Pharmacokinetics

    • Hermann Tenor, Armin Hatzelmann, Rolf Beume, Gezim Lahu, Karl Zech, Thomas D. Bethke
    Pages 85-119
  5. Structural Insight into the Substrate Specificity of Phosphodiesterases

    • Hengming Ke, Huanchen Wang, Mengchun Ye
    Pages 121-134
  6. A Fission Yeast-Based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity

    • Didem Demirbas, Ozge Ceyhan, Arlene R. Wyman, Charles S. Hoffman
    Pages 135-149
  7. The GAF-Tandem Domain of Phosphodiesterase 5 as a Potential Drug Target

    • Joachim E. Schultz, Torsten Dunkern, Elvira Gawlitta-Gorka, Gabriele Sorg
    Pages 151-166
  8. Small Molecule Allosteric Modulators of Phosphodiesterase 4

    • Mark E. Gurney, Alex B. Burgin, Olafur T. Magnusson, Lance J. Stewart
    Pages 167-192
  9. Phosphodiesterases as Targets for Intermittent Claudication

    • Yongge Liu, Yasmin Shakur, Junichi Kambayashi
    Pages 211-236
  10. Phosphodiesterase Inhibition in Heart Failure

    • Matthew A. Movsesian, Rakesh C. Kukreja
    Pages 237-249
  11. Role of Phosphodiesterases in Adult-Onset Pulmonary Arterial Hypertension

    • F. Murray, M. R. MacLean, P. A. Insel
    Pages 279-305
  12. Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy

    • Justin M. Percival, Candace M. Adamo, Joseph A. Beavo, Stanley C. Froehner
    Pages 323-344
  13. Phosphodiesterases as Targets for Modulating T-Cell Responses

    • Elisa Bjørgo, Kristine Moltu, Kjetil Taskén
    Pages 345-363
  14. Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation

    • Angie L. Hertz, Joseph A. Beavo
    Pages 365-390
  15. Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders

    • Ying Xu, Han-Ting Zhang, James M. O’Donnell
    Pages 447-485

About this book

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

Editors and Affiliations

  • School of Medicine, Dept. Molecular Physiology & Biophysics, Vanderbilt University, Nashville, USA

    Sharron H. Francis

  • HSW 1656, Center for Reproductive Sciences, San Francisco, USA

    Marco Conti

  • Wolfson Building, University of Glasgow, Glasgow, United Kingdom

    Miles D. Houslay

Bibliographic Information

Buy it now

Buying options

eBook USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access