Heart Rate and Rhythm

1. Front Matter

   Pages i-xxii

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2. Normal Cardiac Rhythm and Pacemaker Activity

   1. Front Matter

      Pages 1-1

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   2. Cardiac Ion Channels and Heart Rate and Rhythm

      • Onkar Nath Tripathi

      Pages 3-31

   3. Ionic Basis of the Pacemaker Activity of SA Node Revealed by the Lead Potential Analysis

      • Yukiko Himeno, Chae Young Cha, Akinori Noma

      Pages 33-58

   4. The “Funny” Pacemaker Current

      • Andrea Barbuti, Annalisa Bucchi, Raffaella Milanesi, Georgia Bottelli, Alessia Crespi, Dario DiFrancesco

      Pages 59-81

   5. Novel Perspectives on Cardiac Pacemaker Regulation: Role of the Coupled Function of Sarcolemmal and Intracellular Proteins

      • Victor A. Maltsev, Tatiana M. Vinogradova, Edward G. Lakatta

      Pages 83-99

   6. Pacemaker Activity of the SA Node: Insights from Dynamic-Clamp Experiments

      • Ronald Wilders, Antoni C. G. van Ginneken, Arie O. Verkerk

      Pages 101-117

   7. Heart Rate Variability: Molecular Mechanisms and Clinical Implications

      • Kishore K. Deepak

      Pages 119-132

   8. Mechano-Electric Feedback in the Heart: Effects on Heart Rate and Rhythm

      • T. Alexander Quinn, Rebecca A. Bayliss, Peter Kohl

      Pages 133-151

3. Modeling

   1. Front Matter

      Pages 153-153

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   2. A Historical Perspective on the Development of Models of Rhythm in the Heart

      • Penelope J. Noble, Denis Noble

      Pages 155-173

   3. Simulation of Cardiac Action Potentials

      • Jonathan D. Moreno, Colleen E. Clancy

      Pages 175-194

4. Cardiac Development and Anatomy

   1. Front Matter

      Pages 195-195

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   2. Development of Pacemaker Activity in Embryonic and Embryonic Stem Cell-Derived Cardiomyocytes

      • Huamin Liang, Michael Reppel, Ming Tang, Jürgen Hescheler

      Pages 197-209

   3. Molecular Basis of the Electrical Activity of the Atrioventricular Junction and Purkinje Fibres

      • Halina Dobrzynski, Oliver Monfredi, Ian D. Greener, Andrew Atkinson, Shin Inada, Mary-Anne Taube et al.

      Pages 211-230

   4. Molecular Basis and Genetic Aspects of the Development of the Cardiac Chambers and Conduction System: Relevance to Heart Rhythm

      • Martijn L. Bakker, Vincent M. Christoffels, Antoon F. M. Moorman

      Pages 231-253

   5. Role of the T-Tubules in the Response of Cardiac Ventricular Myocytes to Inotropic Interventions

      • C. H. Orchard, F. Brette, A. Chase, M. R. Fowler

      Pages 255-266

5. Mechanisms of Acquired Arrhythmia

   1. Front Matter

      Pages 267-267

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   2. An Overview of Spiral- and Scroll-Wave Dynamics in Mathematical Models for Cardiac Tissue

      • Rupamanjari Majumder, Alok Ranjan Nayak, Rahul Pandit

      Pages 269-282

   3. Post-infarction Remodeling and Arrhythmogenesis: Molecular, Ionic, and Electrophysiological Substrates

      • Nabil El-Sherif

      Pages 283-304

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms.

Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca²⁺ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

• Action potentials
• Arrhythmogenesis
• Atrioventricular junction
• Cardiac pacemaker
• Intracellular Ca
• Ion channels
• Myocard
• Purkinje fibres

From the reviews:

“Heart Rate reigns as one of 2011’s best. Here, physicians are presented with an acute review of how changes in heart rate can be used as a marker to assess patients in the clinical setting. … the writers also extend their treatise to practicing clinicians and ways that the information can be used to better treat patients. Noted for its clear delineation of complex data; with skilled use of illustrations and graphs that re-enforce key points chapter-by-chapter.” (John Aiello, The Electric Review, July, 2011)

• Life Sciences Academy, Lucknow, India

  Onkar N. Tripathi

• Medizinische Fakultät, Inst. für Pharmakologie u. Toxikologie, TU Dresden, Dresden, Germany

  Ursula Ravens

• Cardiovascular Research &, Training Inst. (CVRTI), University of Utah, Salt Lake City, USA

  Michael C. Sanguinetti

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