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Brain, Behavior and Epigenetics

  • Book
  • © 2011

Overview

Editors:
  1. Arturas Petronis

    1. , The Krembil Family Epigenetics Laborator, Centre for Addiction and Mental Health, Toronto, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Jonathan Mill

    1. , Institute of Psychiatry, King's College London, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • Art Petronis' and Jon Mill's research is dedicated to the understanding of the role of epigenetic risk factors in complex diseases
  • Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical developmental stage
  • Epigenetics, a cellular mechanism once considered to be stable after development, has now been found to be a dynamic process that occurs in fully differentiated, post-mitotic cells of central nervous system in response to environmental signals
  • Includes supplementary material: sn.pub/extras

Part of the book series: Epigenetics and Human Health (EHH)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Posttranslational Histone Modifications and the Neurobiology of Psychosis

    • Schahram Akbarian, Iris Cheung, Caroline Connor, Mira Jakovcevski, Yan Jiang
    Pages 1-21

  3. Epigenetic Regulation of GABAergic Targets in Psychiatry

    • Dennis R. Grayson, Marija Kundakovic, Ying Chen, Erbo Dong, Alessandro Guidotti
    Pages 23-40

  4. Possible Roles of DNA Methylation in Bipolar Disorder

    • Tadafumi Kato
    Pages 41-47

  5. The Epigenetics of Depression and Suicide

    • Benoit Labonté, Gustavo Turecki
    Pages 49-70

  6. Epidemiology Research and Epigenetics: Translational Epidemiology of Schizophrenia

    • Mary Perrin, Karine Kleinhaus, Mark Opler, Julie Messinger, Dolores Malaspina
    Pages 71-96

  7. Environmental Studies as a Tool for Detecting Epigenetic Mechanisms in Schizophrenia

    • Wim Veling, L. H. Lumey, Bas Heijmans, Ezra Susser
    Pages 97-118

  8. Imprinting, Inactivation and the Behavioural Genetics of the X Chromosome

    • Ian W. Craig
    Pages 119-141

  9. The Strategies of the Genes: Genomic Conflicts, Attachment Theory, and Development of the Social Brain

    • Bernard J. Crespi
    Pages 143-167

  10. Genomic Imprinting Effects on Brain and Behavior: Future Directions

    • Anthony R. Isles, Lawrence S. Wilkinson
    Pages 169-184

  11. Epigenetic Influence of the Social Environment

    • Frances A. Champagne, James P. Curley
    Pages 185-208

  12. Toward an Understanding of the Dynamic Interdependence of Genes and Environment in the Regulation of Phenotype

    • Ian C. G. Weaver
    Pages 209-243

  13. Histone Deacetylase Inhibitors: A Novel Therapeutic Approach for Cognitive Disorders

    • Viviane Labrie
    Pages 245-266

  14. Epigenetic Mechanisms of Memory Consolidation

    • Marcel A. Estevez, Ted Abel
    Pages 267-285

  15. Epigenetic Mechanisms in Memory Formation

    • Johannes M. H. M. Reul, Andrew Collins, María Gutièrrez-Mecinas
    Pages 287-300

  16. Back Matter

    Pages 301-317
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Keywords

About this book

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Editors and Affiliations

  • , The Krembil Family Epigenetics Laborator, Centre for Addiction and Mental Health, Toronto, Canada

    Arturas Petronis

  • , Institute of Psychiatry, King's College London, London, United Kingdom

    Jonathan Mill

Bibliographic Information

  • Book Title: Brain, Behavior and Epigenetics

  • Editors: Arturas Petronis, Jonathan Mill

  • Series Title: Epigenetics and Human Health

  • DOI: https://doi.org/10.1007/978-3-642-17426-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2011

  • Hardcover ISBN: 978-3-642-17425-4Published: 21 May 2011

  • Softcover ISBN: 978-3-642-26832-8Published: 15 July 2013

  • eBook ISBN: 978-3-642-17426-1Published: 19 May 2011

  • Series ISSN: 2191-2262

  • Series E-ISSN: 2191-2270

  • Edition Number: 1

  • Number of Pages: XVI, 320

  • Topics: Human Genetics, Psychiatry

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