Overview
- Gives overview of the rapidly advancing field of long non-coding RNAs
- Describes the biological functions of long non-coding RNAs in all model systems (from microorganism to mammals)
- Covers epigenetic and non-epigenetic mechanisms of gene regulation through long non-coding RNAs
- Written by experts in the field
- Includes supplementary material: sn.pub/extras
Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 51)
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs.
This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.
Editors and Affiliations
Bibliographic Information
Book Title: Long Non-Coding RNAs
Editors: Durdica Ugarkovic
Series Title: Progress in Molecular and Subcellular Biology
DOI: https://doi.org/10.1007/978-3-642-16502-3
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2011
Hardcover ISBN: 978-3-642-16501-6Published: 05 January 2011
Softcover ISBN: 978-3-642-26655-3Published: 25 February 2013
eBook ISBN: 978-3-642-16502-3Published: 01 February 2011
Series ISSN: 0079-6484
Series E-ISSN: 2197-8484
Edition Number: 1
Number of Pages: XII, 208
Topics: Biochemistry, general, Nucleic Acid Chemistry, Cell Biology, Gene Function, Molecular Medicine