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Behavioral Neurobiology of Bipolar Disorder and its Treatment

  • Book
  • © 2011

Overview

Editors:
  1. Husseini K. Manji

    1. Research & Development, LLC, Johnson & Johnson Pharmaceutical, Titusville, USA

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  2. Carlos A. Zarate Jr.

    1. Mark O. Hatfield Clinical Res. Center, Lab. of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Covers a wide range of methodologies including neuroimaging, genetics and epigenetics, animal models, translational research and psychopharmacology
  • Describes the most effective currently available treatments for the disorder as well as potential novel therapeutics
  • Brings together a group of widely-respected investigators in various fields to provide the reader with the most specific and up-to-date findings
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Behavioral Neurosciences (CTBN, volume 5)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Course and Outcome of Bipolar Disorder

    • Philip B. Mitchell, Dusan Hadzi-Pavlovic, Colleen K. Loo
    Pages 1-18

  3. Genetics of Bipolar Disorder

    • Jens R. Wendland, Francis J. McMahon
    Pages 19-30

  4. Understanding Bipolar Disorder: The Epigenetic Perspective

    • Tarang Khare, Mrinal Pal, Arturas Petronis
    Pages 31-49

  5. Clinical Endophenotypes for Bipolar Disorder

    • David C. Glahn, Katherine E. Burdick
    Pages 51-67

  6. Strategies for the Development of Animal Models for Bipolar Disorder: New Opportunities and New Challenges

    • Haim Einat
    Pages 69-87

  7. Partial Rodent Genetic Models for Bipolar Disorder

    • Guang Chen, Ioline D. Henter, Husseini K. Manji
    Pages 89-106

  8. The Role of the Aminergic Systems in the Pathophysiology of Bipolar Disorder

    • Espen Walderhaug, Monica Varga, Michelle San Pedro, Jian Hu, Alexander Neumeister
    Pages 107-126

  9. The Neurobiology of Bipolar Disorder: From Circuits to Cells to Molecular Regulation

    • Francine M. Benes
    Pages 127-138

  10. Signal Transduction Pathways in the Pathophysiology of Bipolar Disorder

    • Jeremy W. Gawryluk, L. Trevor Young
    Pages 139-165

  11. Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar Disorder

    • Jing Du, Rodrigo Machado-Vieira, Rushaniya Khairova
    Pages 167-185

  12. Mitochondrial Dysfunction and Bipolar Disorder

    • Tadafumi Kato
    Pages 187-200

  13. Neuroimaging and Neuropathological Findings in Bipolar Disorder

    • Jonathan Savitz, Wayne C. Drevets
    Pages 201-225

  14. Functional Neuroimaging Research in Bipolar Disorder

    • Benjamin N. Blond, Hilary P. Blumberg
    Pages 227-245

  15. Sleep and Circadian Rhythm Abnormalities in the Pathophysiology of Bipolar Disorder

    • Jessica Levenson, Ellen Frank
    Pages 247-262

  16. Pharmacological Treatments for Bipolar Disorder: Present Recommendations and Future Prospects

    • Charles L. Bowden
    Pages 263-283

  17. Nonpharmacotherapeutic Somatic Treatments for Bipolar Disorder (ECT, DBS, rTMS)

    • Colleen Loo, Benjamin Greenberg, Philip Mitchell
    Pages 285-302

  18. Potential Novel Therapeutics for Bipolar Disorders

    • Rodrigo Machado-Vieira, Husseini K. Manji, Carlos A. Zarate Jr.
    Pages 303-329

  19. Bipolar Disorder: A Neurobiological Synthesis

    • Husseini K. Manji, Ioline D. Henter, Carlos A. Zarate Jr.
    Pages 331-340

  20. Back Matter

    Pages 341-347
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Keywords

About this book

This book offers the most up-to-date information about research surrounding the neurobiology of bipolar disorder as well as currently available and novel therapeutic options. The volume has assembled a widely respected group of preclinical and clinical researchers who bring their expertise to bear upon this illness by reviewing cutting-edge research and clinical evidence regarding the pathophysiology and treatment of bipolar disorder. Early chapters review the course and outcome and genetics of this highly heritable condition, including chapters on epigenetics and clinical endophenotypes. Several chapters offer a remarkably thorough and unique overview of the neurobiology of the disorder, including what is known from neuroimaging work and the development of animal models. Finally, the book covers treatment strategies for bipolar disorder, including both traditional and novel therapeutics, as well as non-pharmacological treatments. It offers both researchers and clinicians key insights into this devastating disorder.

Editors and Affiliations

  • Research & Development, LLC, Johnson & Johnson Pharmaceutical, Titusville, USA

    Husseini K. Manji

  • Mark O. Hatfield Clinical Res. Center, Lab. of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, USA

    Carlos A. Zarate Jr.

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