Authors:
- First book on Complex Systems Science And Systems Biology of Cancer with outstanding importance for systems biology and tumour modeling
- Contains advanced mathematical and computation principles applied to complex systems theory using tumours as an example
- Includes an in-depth critical study of the current state of the literature concerning modelling and simulation of tumour systems
Part of the book series: Understanding Complex Systems (UCS)
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Table of contents (7 chapters)
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Front Matter
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Back Matter
About this book
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale.
A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules.
The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.
Authors and Affiliations
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Pinaki, UK
Manish Patel
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UCL Cancer Institute, London, UK
Sylvia Nagl
Bibliographic Information
Book Title: The Role of Model Integration in Complex Systems Modelling
Book Subtitle: An Example from Cancer Biology
Authors: Manish Patel, Sylvia Nagl
Series Title: Understanding Complex Systems
DOI: https://doi.org/10.1007/978-3-642-15603-8
Publisher: Springer Berlin, Heidelberg
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer Berlin Heidelberg 2010
Hardcover ISBN: 978-3-642-15602-1Published: 08 September 2010
Softcover ISBN: 978-3-642-42295-9Published: 15 October 2014
eBook ISBN: 978-3-642-15603-8Published: 02 October 2010
Series ISSN: 1860-0832
Series E-ISSN: 1860-0840
Edition Number: 1
Number of Pages: X, 168
Topics: Complexity, Complex Systems, Systems Biology, Cancer Research, Statistical Physics and Dynamical Systems