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Copper-Catalyzed Multi-Component Reactions

Synthesis of Nitrogen-Containing Polycyclic Compounds

  • Book
  • © 2011

Overview

Authors:
  1. Yusuke Ohta

    1. , Graduate School of Pharmaceutical Scienc, Kyoto University, Kyoto, Japan

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  • Nominated by the University of Kyoto (Pharmaceutical Sciences), Japan for a Springer
  • The work of the thesis will inspire synthetic research of many readers.
  • This research is the first example of a three-component Indole formation without producing salts as a byproduct.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Introduction

    • Yusuke Ohta
    Pages 1-6

  3. Conclusions

    • Yusuk Ohta
    Pages 101-102
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Keywords

About this book

A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.

Authors and Affiliations

  • , Graduate School of Pharmaceutical Scienc, Kyoto University, Kyoto, Japan

    Yusuke Ohta

Bibliographic Information

  • Book Title: Copper-Catalyzed Multi-Component Reactions

  • Book Subtitle: Synthesis of Nitrogen-Containing Polycyclic Compounds

  • Authors: Yusuke Ohta

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-642-15473-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2011

  • Hardcover ISBN: 978-3-642-15472-0Published: 30 January 2011

  • Softcover ISBN: 978-3-642-26701-7Published: 25 February 2013

  • eBook ISBN: 978-3-642-15473-7Published: 20 January 2011

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XVI, 104

  • Topics: Organic Chemistry, Medicinal Chemistry

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