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Drug Transporters

  • Book
  • © 2011

Overview

Editors:
  1. Martin F. Fromm

    1. Inst. Experimentelle und Klinische, Pharmakologie und Toxikologie, Universität Erlangen-Nürnberg, Erlangen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard B. Kim

    1. Division of Clinical Pharmacology, University of Western Ontario, London, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • This book provides a comprehensive overview of key drug transporters.
  • It highlights mechanisms of drug absorption, elimination and drug-drug interactions and discusses the role of drug transporters for drug development
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 201)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. Uptake Transporters of the Human OATP Family

    • Jörg König
    Pages 1-28

  3. In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) in Drug Therapy

    • Gerhard Burckhardt, Birgitta Christina Burckhardt
    Pages 29-104

  4. Organic Cation Transporters (OCTs, MATEs), In Vitro and In Vivo Evidence for the Importance in Drug Therapy

    • Anne T. Nies, Hermann Koepsell, Katja Damme, Matthias Schwab
    Pages 105-167

  5. Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition

    • Paul A. Dawson
    Pages 169-203

  6. The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation

    • Bruno Stieger
    Pages 205-259

  7. P-glycoprotein: Tissue Distribution, Substrates, and Functional Consequences of Genetic Variations

    • Ingolf Cascorbi
    Pages 261-283

  8. Importance of P-glycoprotein for Drug–Drug Interactions

    • Hartmut Glaeser
    Pages 285-297

  9. Multidrug Resistance Proteins (MRPs, ABCCs): Importance for Pathophysiology and Drug Therapy

    • Dietrich Keppler
    Pages 299-323

  10. In Vitro and In Vivo Evidence for the Importance of Breast Cancer Resistance Protein Transporters (BCRP/MXR/ABCP/ABCG2)

    • Henriette E. Meyer zu Schwabedissen, Heyo K. Kroemer
    Pages 325-371

  11. Molecular Mechanisms of Drug Transporter Regulation

    • Rommel G. Tirona
    Pages 373-402

  12. In Vivo Probes of Drug Transport: Commonly Used Probe Drugs to Assess Function of Intestinal P-glycoprotein (ABCB1) in Humans

    • Stefan Oswald, Bernd Terhaag, Werner Siegmund
    Pages 403-447

  13. Back Matter

    Pages 449-454
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Keywords

About this book

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Editors and Affiliations

  • Inst. Experimentelle und Klinische, Pharmakologie und Toxikologie, Universität Erlangen-Nürnberg, Erlangen, Germany

    Martin F. Fromm

  • Division of Clinical Pharmacology, University of Western Ontario, London, Canada

    Richard B. Kim

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