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Cancer Immunology and Immunotherapy

  • Book
  • © 2011

Overview

Editors:
  1. Glenn Dranoff

    1. , Medical Oncology/Hematologic Neoplasial, Dana-Farber Cancer Institute, Boston, USA

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  • The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies.
  • The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 344)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Immune Infiltration in Human Cancer: Prognostic Significance and Disease Control

    • Wolf H. Fridman, Jérome Galon, Marie-Caroline Dieu-Nosjean, Isabelle Cremer, Sylvain Fisson, Diane Damotte et al.
    Pages 1-24

  3. Subversion and Coercion: The Art of Redirecting Tumor Immune Surveillance

    • John B. Mumm, Martin Oft
    Pages 25-39

  4. STAT3: A Target to Enhance Antitumor Immune Response

    • Heehyoung Lee, Sumanta Kumar Pal, Karen Reckamp, Robert A. Figlin, Hua Yu
    Pages 41-59

  5. Biology and Clinical Observations of Regulatory T Cells in Cancer Immunology

    • Michele W. L. Teng, David S. Ritchie, Paul Neeson, Mark J. Smyth
    Pages 61-95

  6. Concepts and Ways to Amplify the Antitumor Immune Response

    • Bent Rubin, Jean Edouard Gairin
    Pages 97-128

  7. Angiogenesis and the Tumor Vasculature as Antitumor Immune Modulators: The Role of Vascular Endothelial Growth Factor and Endothelin

    • Lana E. Kandalaft, Gregory T. Motz, Johanna Busch, George Coukos
    Pages 129-148

  8. Adoptive Cellular Therapy

    • Stephan A. Grupp, Carl H. June
    Pages 149-172

  9. Dendritic Cell Subsets as Vectors and Targets for Improved Cancer Therapy

    • Karolina Palucka, Hideki Ueno, Lee Roberts, Joseph Fay, Jacques Banchereau
    Pages 173-192

  10. Identification of Human Idiotype-Specific T Cells in Lymphoma and Myeloma

    • Jinsheng Weng, Sattva S. Neelapu, Alison F. Woo, Larry W. Kwak
    Pages 193-210

  11. Modulation of CTLA-4 and GITR for Cancer Immunotherapy

    • Francesca Avogadri, Jianda Yuan, Arvin Yang, David Schaer, Jedd D. Wolchok
    Pages 211-244

  12. Immunobiology of Cancer Therapies Targeting CD137 and B7-H1/PD-1 Cosignal Pathways

    • Shengdian Wang, Lieping Chen
    Pages 245-267

  13. LAG-3 in Cancer Immunotherapy

    • Monica V. Goldberg, Charles G. Drake
    Pages 269-278

  14. Immunologically Active Biomaterials for Cancer Therapy

    • Omar A. Ali, David J. Mooney
    Pages 279-297

  15. Erratum to: Identification of Human Idiotype-Specific T Cells in Lymphoma and Myeloma

    • Jinsheng Weng, Sattva S. Neelapu, Alison F. Woo, Larry W. Kwak
    Pages 299-299

  16. Back Matter

    Pages 301-304
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Keywords

About this book

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Reviews

From the reviews:

“This book comprises 13 reviews, contributed by members of a cross-section of groups working in the … field of cancer immunology. … this book is at its best when considering small and apparently discrete topics ­­– its strength comes from being able to read all of these ideas on one place. … Overall, this book gives a thorough and detailed overview of the current state of basic and translational research into cancer immunology … . It’s probably most appropriate for researchers … .”­­­ (Victoria Lawson, Immunology News, November, 2011)

Editors and Affiliations

  • , Medical Oncology/Hematologic Neoplasial, Dana-Farber Cancer Institute, Boston, USA

    Glenn Dranoff

Bibliographic Information

  • Book Title: Cancer Immunology and Immunotherapy

  • Editors: Glenn Dranoff

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-14136-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2011

  • Hardcover ISBN: 978-3-642-14135-5Published: 15 April 2011

  • Softcover ISBN: 978-3-642-26788-8Published: 29 May 2013

  • eBook ISBN: 978-3-642-14136-2Published: 11 April 2011

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIV, 306

  • Topics: Cancer Research, Immunology

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