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  • © 2010

Diverse Effects of Hypoxia on Tumor Progression

  • Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 345)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-x
  2. Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression

    • Amato J. Giaccia, Ernestina Schipani
    Pages 31-45
  3. The Role of Hypoxia Regulated microRNAs in Cancer

    • Robert McCormick, Francesca M. Buffa, Jiannis Ragoussis, Adrian L. Harris
    Pages 47-70
  4. Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration

    • Annelies Quaegebeur, Peter Carmeliet
    Pages 71-103
  5. Hypoxia-Inducible Factors as Essential Regulators of Inflammation

    • Hongxia Z. Imtiyaz, M. Celeste Simon
    Pages 105-120
  6. Hypoxia and Metastasis in Breast Cancer

    • Helene Rundqvist, Randall S. Johnson
    Pages 121-139
  7. Back Matter

    Pages 141-143

About this book

Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Editors and Affiliations

  • Medicine, University of Pennsylvania School of, Philadelphia, USA

    M. Celeste Simon

Bibliographic Information

  • Book Title: Diverse Effects of Hypoxia on Tumor Progression

  • Editors: M. Celeste Simon

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-13329-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2010

  • Hardcover ISBN: 978-3-642-13328-2Published: 05 September 2010

  • Softcover ISBN: 978-3-642-26484-9Published: 05 November 2012

  • eBook ISBN: 978-3-642-13329-9Published: 28 September 2010

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 146

  • Topics: Cancer Research, Embryology, Human Physiology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access