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RNA Technologies and Their Applications

  • Book
  • © 2010

Overview

Editors:
  1. Volker A. Erdmann

    1. Inst. Chemie und Biochemie, FU Berlin, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Jan Barciszewski

    1. Inst. Bioorganic Chemistry, PAN Poznan, Poznan, Poland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • RNA mediated gene silencing is a powerful technology to downregulate the expression of targeted genes within the cell.
  • Now RNA interference based therapeutics is to be released.
  • This book provides a state-of-the-art review concerning the molecular basis as well as applications of RNA based technologies in molecular biology and medicine.
  • These topics are covered by 19 contributions written by internationally respected experts in the field of RNA Technologies.
  • Includes supplementary material: sn.pub/extras

Part of the book series: RNA Technologies (RNATECHN)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvi
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  2. The Key Features of RNA Silencing

    • Kuniaki Saito, Keita Miyoshi, Mikiko C. Siomi, Haruhiko Siomi
    Pages 1-28

  3. Selected Strategies for the Delivery of siRNA In Vitro and In Vivo

    • Sandra D. Laufer, Anke Detzer, Georg Sczakiel, Tobias Restle
    Pages 29-58

  4. RNAi Suppression and Its Application

    • Xiaoping Yi, Rui Lu
    Pages 59-92

  5. Strategies to Prevent siRNA-Triggered Cellular Toxicity

    • Matthias Bauer
    Pages 93-106

  6. RNAi in Malignant Brain Tumors: Relevance to Molecular and Translational Research

    • Mitsutoshi Nakada, Daisuke Kita, Yutaka Hayashi, Kazuyuki Kawakami, Jun-ichiro Hamada, Toshinari Minamoto
    Pages 107-129

  7. Silencing Huntington’s Disease Gene with RNAi

    • Yu Zhang, Robert M. Friedlander
    Pages 131-160

  8. Application of Dicer-Substrate siRNA in Pain Research

    • Philippe Sarret, Louis Doré-Savard, Pascal Tétreault, Valérie Bégin-Lavallée, Nicolas Beaudet
    Pages 161-190

  9. RNAi Treatment of HIV-1 Infection

    • Karin J. von Eije, Ben Berkhout
    Pages 191-208

  10. Application of RNA Interference to Treat Conditions Associated with Dysregulation of Transient Receptor Potential Vanilloid 1 Channel

    • Vickram Ramkumar, Debashree Mukherjea, Sarvesh Jajoo, Tejbeer Kaur, Leonard P. Rybak
    Pages 209-226

  11. Harnessing RNAi-Based Functional Genomics to Unravel the Molecular Complexity Underlying Skin Pigment Variation

    • Hsiang Ho, Jayavani Aruri, Safoora Ahmed, Anand K. Ganesan
    Pages 227-253

  12. mRNA Structure and its Effects on Posttranscriptional Gene Silencing

    • Stephen I. Rudnick, Veenu Aishwarya, Alan M. Gewirtz
    Pages 255-275

  13. Antisense RNA-Mediated Regulation of the p53 Tumor Suppressor

    • Marianne Farnebo, Klas G. Wiman
    Pages 277-284

  14. Antisense Oligonucleotides: Insights from Preclinical Studies and Clinical Trials

    • Doreen Kunze, Kai Kraemer, Susanne Fuessel
    Pages 285-303

  15. What can the New Hammerhead Ribozyme Structures Teach us About Design?

    • William G. Scott
    Pages 305-323

  16. microRNA Biogenesis and its Impact on RNA Interference

    • Stefanie Grund, Sven Diederichs
    Pages 325-354

  17. MicroRNAs in Epithelial Antimicrobial Immunity

    • Jun Liu, Guoku Hu, Rui Zhou, Kristen M. Drescher, Xian-Ming Chen
    Pages 355-367

  18. Emerging Roles of Long Noncoding RNAs in Gene Expression and Intracellular Organization

    • Tetsuro Hirose
    Pages 369-391

  19. Noncoding RNAs as Therapeutic Targets

    • Maciej SzymaÅ„ski, Jan Barciszewski
    Pages 393-418

  20. Noncoding RNAs at H19/IGF2 Locus: Role in Imprinting, Gene Expression, and Associated Pathologies

    • Nahalie Berteaux, Nathalie Spruyt, Eric Adriaenssens
    Pages 419-443
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Keywords

About this book

RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.

Editors and Affiliations

  • Inst. Chemie und Biochemie, FU Berlin, Berlin, Germany

    Volker A. Erdmann

  • Inst. Bioorganic Chemistry, PAN Poznan, Poznan, Poland

    Jan Barciszewski

Bibliographic Information

  • Book Title: RNA Technologies and Their Applications

  • Editors: Volker A. Erdmann, Jan Barciszewski

  • Series Title: RNA Technologies

  • DOI: https://doi.org/10.1007/978-3-642-12168-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2010

  • Hardcover ISBN: 978-3-642-12167-8Published: 06 September 2010

  • Softcover ISBN: 978-3-642-26490-0Published: 06 November 2012

  • eBook ISBN: 978-3-642-12168-5Published: 02 September 2010

  • Series ISSN: 2197-9731

  • Series E-ISSN: 2197-9758

  • Edition Number: 1

  • Number of Pages: XVI, 452

  • Number of Illustrations: 39 b/w illustrations, 30 illustrations in colour

  • Topics: Human Physiology, Cell Biology, Biochemistry, general, Molecular Medicine, Nucleic Acid Chemistry, Human Genetics

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