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Mitochondrial Genetics and Cancer

  • Book
  • © 2010

Overview

Authors:
  1. Gabriel D. Dakubo

    1. Genesis Genomics, Inc., Thunder Bay, Canada

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  • Unique compilation of mitochondrial genome alterations in cancer.

  • State-of-the-art contents.

  • The editor is one of the leading experts in the field.

  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xv
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  2. General Overview of Mitochondrial Genetics and Functions

    1. Front Matter

      Pages 1-1
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    2. Basic Mitochondrial Genetics, Bioenergetics, and Biogenesis

      • Gabriel D. Dakubo
      Pages 3-38

    3. The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells

      • Gabriel D. Dakubo
      Pages 39-66

    4. Mitochondrial Control of Apoptosis and Cancer

      • Gabriel D. Dakubo
      Pages 67-92

    5. Mitochondrial-to-Nuclear Communications in Cancer

      • Gabriel D. Dakubo
      Pages 93-115

  3. Mitochondrial Genetic Alterations in Cancer

    1. Front Matter

      Pages 118-118
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    2. Types of Mitochondrial Genetic Alterations in Cancer

      • Gabriel D. Dakubo
      Pages 119-134

    3. Mitochondrial Genetic Alterations in Cancer I

      • Gabriel D. Dakubo
      Pages 135-165

    4. Mitochondrial Genetic Alterations in Cancer II

      • Gabriel D. Dakubo
      Pages 167-185

    5. Mitochondrial Genome Rearrangements and Copy Number Changes in Cancer

      • Gabriel D. Dakubo
      Pages 187-212

    6. Functional Importance of Mitochondrial Genetic Alterations in Cancer

      • Gabriel D. Dakubo
      Pages 213-236

    7. The Role of Mitochondrial Reactive Oxygen Species in Cancer

      • Gabriel D. Dakubo
      Pages 237-256

  5. Back Matter

    Pages 345-356
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Keywords

About this book

With very few exceptions, eukaryotic cells possess two interdependent genomes, chromosomal and extra-chromosomal. Over the past several decades, cancer - search has focused primarily on deciphering the intricate alterations in the chro- somal genome, with until recently, very little attention to its cytoplasmic counterpart. In spite of the enormous complexity of the nuclear genome, which we now fully appreciate after completion of the human genome project, the efforts of cancer researchers are commendable in terms of the tremendous gains made in unraveling the numerous genetic changes in cancer. These changes include d- coveries of tumor suppressor genes, oncogenes, and caretaker genes that are often mutated in cancer. Recent studies of genomic pro?les are uncovering even more altered and mutated genes in cancer. Besides these ?ndings, several therapeutic targets for chemotherapy are currently made from studies of altered nuclear genetic pathways. Inspite of all these positive efforts, the war on cancer, declared in 1971 by Richard Nixon, is far from being worn. Indeed, the failure of chemotherapy is obvious to clinicians, oncologists, and their patients alike. Moreover, the global incidence and prevalence of cancer continue to rise. What are we missing? Which direction should we be taking? Of course, modern integrated nuclear genomics, proteomics, and metabolomics should provide important clues to carcinogenesis, but the contribution of cytoplasmic genetic alterations to carcinogenesis cannot be neglected.

Authors and Affiliations

  • Genesis Genomics, Inc., Thunder Bay, Canada

    Gabriel D. Dakubo

About the author

Gabriel D. Dakubo is the founder of Mito-Onc Consultancy, a pioneer consulting firm that provides evidence-based advice on discovery, validation and regulatory submission of cancer biomarkers based on mitochondrial genomic alterations.

Bibliographic Information

  • Book Title: Mitochondrial Genetics and Cancer

  • Authors: Gabriel D. Dakubo

  • DOI: https://doi.org/10.1007/978-3-642-11416-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2010

  • Hardcover ISBN: 978-3-642-11415-1Published: 13 April 2010

  • Softcover ISBN: 978-3-642-42461-8Published: 28 November 2014

  • eBook ISBN: 978-3-642-11416-8Published: 23 March 2010

  • Edition Number: 1

  • Number of Pages: XV, 356

  • Topics: Human Genetics, Molecular Medicine, Cancer Research

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