The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System

1. Front Matter

   Pages I-IX

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2. The Concept of Neurotropism and Selective Vulnerability (“Pathoclisis”) in Virus Infections of the Nervous System — A Historical Overview

   • G. Gosztonyi, H. Koprowski

   Pages 1-13

3. The Mechanisms of Direct, Virus-Induced Destruction of Neurons

   • J. R. Anderson

   Pages 15-33

4. Slow and Persistent Virus Infections of Neurones — A Compromise for Neuronal Survival

   • U. G. Liebert

   Pages 35-60

5. Neuronal Latency in Human and Animal Herpesvirus Infections

   • K. Borchers, H. J. Field

   Pages 61-94

6. Programmed Cell Death in Virus Infections of the Nervous System

   • J. K. Fazakerley, T. E. Allsopp

   Pages 95-119

7. Interactions of Viral Proteins with Neurotransmitter Receptors May Protect or Destroy Neurons

   • G. Gosztonyi, H. Ludwig

   Pages 121-144

8. Mechanisms of Virus-Induced Neuronal Damage and the Clearance of Viruses from the CNS

   • B. Dietzschold, K. Morimoto, D. C. Hooper

   Pages 145-155

9. Borna Disease Virus Infection of Adult and Neonatal Rats: Models for Neuropsychiatric Disease

   • M. Hornig, M. Solbrig, N. Horscroft, H. Weissenböck, W. I. Lipkin

   Pages 157-177

10. The Mechanisms of Neuronal Damage in Retroviral Infections of the Nervous System

    • V. J. Sanders, C. A. Wiley, R. L. Hamilton

    Pages 179-201

11. Prion-Induced Neuronal Damage — The Mechanisms of Neuronal Destruction in the Subacute Spongiform Encephalopathies

    • A. Giese, H. A. Kretzschmar

    Pages 203-217

12. The Role of T-Cell-Mediated Mechanisms in Virus Infections of the Nervous System

    • R. Dörries

    Pages 219-245

13. Virus-Induced Autoimmune Reactions in the CNS

    • P. J. Talbot, D. Arnold, J. P. Antel

    Pages 247-271

14. Back Matter

    Pages 273-280

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It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. This volume summarizes, for the first time, the various ways that neurons can degenerate under the influence of viral infection, ranging from acute necrosis and virus-induced apoptosis to chronic damage in persistent infections. The mechanisms of neuronal latency are dealt with as well. The volume also includes chapters that review the chronic damage caused by viral proteins that interfere with differentiated functions of the neuron, including signaling by neurotransmitters and signal transduction by trophic factors. Other chapters deal with the controversial role of cellular immune reactions, which may be helpful in controlling infection, but may also be detrimental to the host nervous system. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage.

• Nervous System
• apoptosis
• autoimmune disease
• cell
• infection
• infections
• inflammation
• neurons
• programmed cell death
• protein
• proteins
• receptor
• retroviruses
• virology
• virus

• Universitätsklinikum Benjamin Franklin Abt. für Neuropathologie, FU Berlin, Fachbereich Humanmedizin, Berlin, Germany

  Georg Gosztonyi

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