Bacterial Protein Toxins

1. Front Matter

   Pages I-XXXII

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2. Uptake of Protein Toxins Acting Inside Cells

   • S. Olsnes, J. Wesche, P. Ø. Falnes

   Pages 1-19

3. Common Features of ADP—Ribosyltransferases

   • V. Masignani, M. Pizza, R. Rappuoli

   Pages 21-44

4. Diphtheria Toxin and the Diphtheria-Toxin Receptor

   • T. Umata, K. D. Sharma, E. Mekada

   Pages 45-66

5. Pseudomonas aeruginosa Exotoxin A: Structure/Function, Production, and Intoxication of Eukaryotic Cells

   • S. E. H. West

   Pages 67-89

6. Diphtheria-Toxin-Based Fusion-Protein Toxins Targeted to the Interleukin-2 Receptor: Unique Probes for Cell Biology and a New Therapeutic Agent for the Treatment of Lymphoma

   • J. R. Murphy, J. C. Vanderspek

   Pages 91-107

7. Structure and Function of Cholera Toxin and Related Enterotoxins

   • F. van den Akker, E. Merritt, W. G. J. Hol

   Pages 109-131

8. Mechanism of Cholera Toxin Action: ADP-Ribosylation Factors as Stimulators of Cholera Toxin-Catalyzed ADP-Ribosylation and Effectors in Intracellular Vesicular Trafficking Events

   • W. A. Patton, N. Vitale, J. Moss, M. Vaughan

   Pages 133-165

9. Pertussis Toxin: Structure—Function Relationship

   • C. Locht, R. Antoine, A. Veithen, D. Raze

   Pages 167-185

10. Pertussis Toxin as a Pharmacological Tool

    • B. Nürnberg

    Pages 187-206

11. Clostridium Botulinum C3 Exoenzyme and C3-Like Transferases

    • K. Aktories, H. Barth, I. Just

    Pages 207-233

12. Pseudomonas aeruginosa Exoenzyme S, a Bifunctional Cytotoxin Secreted by a Type-III Pathway

    • J. T. Barbieri, D. W. Frank

    Pages 235-251

13. Structure and Function of Actin-Adenosine-Diphosphate-Ribosylating Toxins

    • I. Ohishi

    Pages 253-273

14. Molecular Biology of Actin-ADP-Ribosylating Toxins

    • M. R. Popoff

    Pages 275-306

15. Molecular Mechanisms of Action of the Large Clostridial Cytotoxins

    • I. Just, F. Hofmann, K. Aktories

    Pages 307-331

16. Molecular Biology of Large Clostridial Toxins

    • J. S. Moncrief, D. M. Lyerly, T. D. Wilkins

    Pages 333-359

17. The Cytotoxic Necrotizing Factor 1 from Escherichia Coli

    • P. Boquet, C. Fiorentini

    Pages 361-384

18. Shiga Toxins of Shigella dysenteriae and Escherichia coli

    • A. R. Melton-Celsa, A. D. O’Brien

    Pages 385-406

19. Clostridial Neurotoxins

    • H. Bigalke, L. F. Shoer

    Pages 407-443

20. Anthrax Toxin

    • S. H. Leppla

    Pages 445-472

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

• Antigen
• Eiweiss
• Gift
• bacterial protein toxin
• cell biology
• cell entry
• enzyme
• enzymes
• pore formation
• toxin structure

• Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg i. Br., Germany

  Klaus Aktories, Ingo Just

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