Red Cell Membrane Transport in Health and Disease

1. Front Matter

   Pages I-XXVIII

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2. Distribution and Movement of Membrane Lipids

   • Cees W. M. Haest

   Pages 1-25

3. Membrane Lipids and Proteins as a Basis of Red Cell Shape and its Alterations

   • Bernhard Deuticke

   Pages 27-60

4. Human Red Cell Shape and the Mechanical Characteristics of the Membrane

   • Thomas M. Fischer

   Pages 61-82

5. Passive Membrane Permeability for Ions and the Membrane Potential

   • Ingolf Bernhardt, Erwin Weiss

   Pages 83-109

6. Na+/K+ Pump

   • John R. Sachs

   Pages 111-137

7. Ion Channels

   • Poul Bennekou, Palle Christophersen

   Pages 139-152

8. The Swelling-Sensitive Osmolyte Channel

   • René Motais, Hélène Guizouarn, Franck Borgese

   Pages 153-171

9. Na+-K+-2Cl- Cotransport

   • Christian Lytle

   Pages 173-195

10. K+-Cl- Cotransport in Vertebrate Red Cells

    • John S. Gibson, J. Clive Ellory

    Pages 197-220

11. The Band 3 Protein: Anion Exchanger and Anion-Proton Cotransporter

    • Sigrid Lepke, Joachim Heberle, Hermann Passow

    Pages 221-252

12. Band 3 Mediated Transport

    • Philip A. Knauf, Prithwish Pal

    Pages 253-301

13. Amino Acid Transport

    • J. Clive Ellory, Pawel Swietach, John S. Gibson

    Pages 303-319

14. Equilibrative Nucleoside Transport Proteins

    • James D. Young, Sylvia Y. M. Yao, Carol E. Cass, Stephen A. Baldwin

    Pages 321-337

15. Glucose Transport

    • Richard J. Naftalin

    Pages 339-372

16. Calcium Homeostasis in Normal and Abnormal Human Red Cells

    • Teresa Tiffert, Robert M. Bookchin, Virgilio L. Lew

    Pages 373-405

17. Magnesium Transport

    • Peter W. Flatman

    Pages 407-434

18. Trace Metal Transport

    • Niall M. Horn, Alan L. Thomas, Fiona Oakley

    Pages 435-450

19. Monocarboxylate and other Organic Anion Transport

    • Andrew P. Halestrap

    Pages 451-476

20. Water Permeability

    • Joseph Browning, Robert Wilkins

    Pages 477-488

The red cell has been a focus for scientific and medical investigation since the ear­ liest times. A higher erythrocyte sedimentation rate was associated with diseases (usually pyrexias) before the thermometer was invented. Furthermore, ever since the early observers Swammerdam and Leeuvenhoek saw discrete corpuscles in samples of blood using the first microscopes, there has been a significant scientific interest in the structure and function of red blood cells. The later discovery that red cells were not spherical, but biconcave discs introduced a scientific puzzle which is still not completely resolved today, and identified the need for a detailed knowledge of the plasma membrane composition and structure, and its interaction with the cytoskeleton. Important concepts like the lipid bilayer, together with its more recent refinement as asymmetric in phospholipid composition led to the identification of translocases involved in actively maintaining its composition. Understanding the mechanics of red cell deformation as these biconcave discs traverse capillaries was advanced by the pioneering work of Rand and Burton in the Sixties, and progressed by Evans, Skalak and others. Based on the bilayer­ couple hypothesis, the shape changes that are possible for a human red cell from echinocyte to stomatocyte were described by Sheetz and Singer in the Seventies in terms of alterations in the individual halves of the bilayer. Certain clinical condi­ tions are associated with obvious changes in red cell morphology.

• Transporter
• biomechanics
• biophysics
• blood
• blood cell
• cell
• cell membrane
• cells
• dynamics
• erythrocyte
• mechanics
• membrane
• pathophysiology
• physiology
• water

From the reviews:

"Membrane transport is a multi-faceted topic that can be looked at from various angles: biochemical, biophysical, cell biological. ‘Red Cell Membrane Transport in Health and Disease’ features contributions … from all of these areas, rendering a rather comprehensive treatise. … Bringing together chemically and physically oriented membrane researchers, the editors have assembled an impressive and varied body of knowledge that ought to be of interest in any laboratory involved in membrane transport research … ." (T. A. Lazar, Hämostaseologie, Issue 3, 2005)

• Naturwissenschaftlich-Technische Fakultät III, Arbeitsgruppe Biophysik, Universität des Saarlandes, Saarbrücken, Germany

  Ingolf Bernhardt

• Laboratory of Physiology, University of Oxford, Oxford, UK

  J. Clive Ellory

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