The Interface Between Innate and Acquired Immunity

1. Front Matter

   Pages I-XIII

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2. The Relationship of Inflammation and Initiation of Autoimmune Disease: Role of TNF Super Family Members

   • R. A. Flavell

   Pages 1-9

3. Surface Receptors that Regulate the NK Cell Function: Beyond the NK Cell Scope

   • L. Moretta, R. Biassoni, C. Bottino, M. C. Mingari, A. Moretta

   Pages 11-22

4. Checkpoints in the Regulation of T Helper 1 Responses

   • V. L. Heath, H. Kurata, H. J. Lee, N. Arai, A. O’Garra

   Pages 23-39

5. The Role of Complement in Innate and Adaptive Immunity

   • J. E. Volanakis

   Pages 41-56

6. Several MHC-Linked Ig Superfamily Genes Have Features of Ancestral Antigen-Specific Receptor Genes

   • L. Du Pasquier

   Pages 57-71

7. Coat Protein Transgenic Papaya: “Acquired” Immunity for Controlling Papaya Ringspot Virus

   • D. Gonsalves

   Pages 73-83

8. Fc Receptor Homologs (FcRH1-5) Extend the Fc Receptor Family

   • R. S. Davis, G. Dennis Jr., H. Kubagawa, M. D. Cooper

   Pages 85-112

9. Back Matter

   Pages 113-118

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All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobial peptides has been de­ fined. A variety of cell surface receptors that recognize common patterns displayed by infectious organisms have been identified along with the intracellular pathways that these receptors use to activate cellular defense functions. Cell surface receptors on natural killer (NK) cells have been shown to sense microbial invasion in neighboring cells, thereby setting into motion their elimination by cy­ totoxic mechanisms. Other receptors have been found to facilitate phagocytosis and intracellular killing of microbes by phagocytic cells. These and other natural defense mechanisms have traditionally been viewed as the first line of body defense in vertebrate species that also possess the capacity for acquired or adaptive immunity. Sharks and all of the other jawed vertebrates generate large repertoires of T and B lymphocyte clones that display different antigen­ specific receptors in the form ofT cell receptors (TCR) and immunoglobulins (Ig) that allow them to recognize and respond to antigens in collaboration with antigen-present­ ing cells. Memory T and B cells are then generated to allow faster and heightened cellular and humoral immune re­ sponses on secondary antigen encounter. In recent years it has also become obvious that innate immune responses can directly influence adaptive immune responses in ways that will enhance body defense.

• Antigen
• NK cells
• T cell
• T helper cells
• antigen-specific receptor genes
• autoimmune disease
• genes
• histocompatibility
• immunity
• necrosis
• phylogeny
• protein
• virus

• Howard Hughes Medical Institute Research Laboratories, University of Alabama at Birmingham, Birmingham, USA

  Max D. Cooper

• Department of Microbiology and Immunology Center for Neurobiology, Jefferson Alumni Hall, Jefferson Medical College, Philadelphia, USA

  Hilary Koprowski

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