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IGFs:Local Repair and Survival Factors Throughout Life Span

  • Book
  • © 2010

Overview

Editors:
  1. David Clemmons

    1. Chapel Hill, University of North Carolina, Chapel Hill, U.S.A.

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  2. Iain C.A.F. Robinson

    1. Lab. Endocrine Physiology, National Inst. Med. Research, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  3. Yves Christen

    1. Recherche Therapeutique, Fondation IPSEN pour la, Boulogne Billancourt Cedex, France

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Part of the book series: Research and Perspectives in Endocrine Interactions (RPEI)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xiii
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  2. GH & IGF1: Aspects of Global and Local Release and Actions

    • Iain C. A. F. Robinson
    Pages 1-10

  3. Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation

    • David R. Clemmons, Laura A Maile, Walker H Busby Jr, Timothy Nichols, Yan Ling, Jarkaslava Lieskovska et al.
    Pages 11-20

  4. IGFBP2 Supports ex vivo Expansion of Hematopoietic Stem Cells

    • HoangDinh Huynh, Megan Kaba, Sonali Rudra, Junke Zheng, Catherine J. Wu, Harvey F. Lodish et al.
    Pages 21-41

  5. The Role of Insulin-like Growth Factor-I in Central Nervous System Development

    • A. Joseph D’Ercole, Ping Ye
    Pages 43-58

  6. Stimulation of Proliferative Pathways by IGF-binding Proteins

    • Robert C. Baxter, Mike Lin, Janet L. Martin
    Pages 59-68

  7. Signaling Pathways that Regulate C. elegans Life Span

    • Gary Ruvkun, Andrew V. Samuelson, Christopher E. Carr, Sean P. Curran, David E. Shore
    Pages 69-84

  8. IGF-1 Regulation of Skeletal Muscle Hypertrophy and Atrophy

    • David J. Glass
    Pages 85-96

  9. Growth Hormone, Insulin-like Growth Factor I and Insulin: their Relationship to Aging and Cancer

    • Ruslan Novosyadlyy, Emily J. Gallagher, Derek LeRoith
    Pages 97-104

  10. The Functions of Insulin-like Peptides in Insects

    • Sebastian Grönke, Linda Partridge
    Pages 105-124

  11. IGF Receptors in the Adult Brain

    • Carlos De Magalhaes Filho, Martin Holzenberger
    Pages 125-142

  12. The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span

    • Nir Barzilai, Derek M. Huffman, Pinchas Cohen, Radhika H. Muzumdar
    Pages 143-153

  13. Back Matter

    Pages 155-157
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Keywords

About this book

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

Editors and Affiliations

  • Chapel Hill, University of North Carolina, Chapel Hill, U.S.A.

    David Clemmons

  • Lab. Endocrine Physiology, National Inst. Med. Research, London, United Kingdom

    Iain C.A.F. Robinson

  • Recherche Therapeutique, Fondation IPSEN pour la, Boulogne Billancourt Cedex, France

    Yves Christen

Bibliographic Information

  • Book Title: IGFs:Local Repair and Survival Factors Throughout Life Span

  • Editors: David Clemmons, Iain C.A.F. Robinson, Yves Christen

  • Series Title: Research and Perspectives in Endocrine Interactions

  • DOI: https://doi.org/10.1007/978-3-642-04302-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2010

  • Hardcover ISBN: 978-3-642-04301-7Published: 03 December 2009

  • Softcover ISBN: 978-3-662-50583-0Published: 23 August 2016

  • eBook ISBN: 978-3-642-04302-4Published: 01 December 2009

  • Series ISSN: 1861-2253

  • Series E-ISSN: 1863-0685

  • Edition Number: 1

  • Number of Pages: XIII, 157

  • Topics: Endocrinology, Human Physiology, Gene Function

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