Skip to main content
SpringerLink
Log in
Book cover

Immunological Synapse

  • Book
  • © 2010

Overview

Editors:
  1. Takashi Saito

    1. Allergy & Immunology, RIKEN Research Center for, okohama City, Kanagawa, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Facundo D. Batista

    1. London Research Institute, Cancer Research UK, London, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 340)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (12 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Insights into Function of the Immunological Synapse from Studies with Supported Planar Bilayers

    • Michael L. Dustin
    Pages 1-24

  3. Immunological Synapses Within Context: Patterns of Cell–Cell Communication and Their Application in T–T Interactions

    • Junsang Doh, Matthew F. Krummel
    Pages 25-50

  4. Molecular and Cellular Dynamics at the Early Stages of Antigen Encounter: The B-Cell Immunological Synapse

    • Yolanda R. Carrasco
    Pages 51-62

  5. Inhibitory and Regulatory Immune Synapses

    • Philipp Eissmann, Daniel M. Davis
    Pages 63-79

  6. The Immunological Synapse, TCR Microclusters, and T Cell Activation

    • Tadashi Yokosuka, Takashi Saito
    Pages 81-107

  7. Signaling Amplification at the Immunological Synapse

    • Antonella Viola, Rita Lucia Contento, Barbara Molon
    Pages 109-122

  8. Multiple Microclusters: Diverse Compartments Within the Immune Synapse

    • Stephen C. Bunnell
    Pages 123-154

  9. A Conformation-Induced Oligomerization Model for B cell Receptor Microclustering and Signaling

    • Pavel Tolar, Susan K. Pierce
    Pages 155-169

  10. Co-Receptors and Recognition of Self at the Immunological Synapse

    • Nicholas R. J. Gascoigne, Tomasz Zal, Pia P. Yachi, John A. H. Hoerter
    Pages 171-189

  11. Vesicle Traffic to the Immunological Synapse: A Multifunctional Process Targeted by Lymphotropic Viruses

    • Andrés Alcover, Maria-Isabel Thoulouze
    Pages 191-207

  12. Plasticity of Immunological Synapses

    • Salvatore Valitutti, Loïc Dupré
    Pages 209-228

  13. APC, T Cells, and the Immune Synapse

    • Peter Reichardt, Bastian Dornbach, Matthias Gunzer
    Pages 229-249

  14. Back Matter

    Pages 251-255
    Download chapter PDF
Back to top

Keywords

About this book

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide–MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide– MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

Editors and Affiliations

  • Allergy & Immunology, RIKEN Research Center for, okohama City, Kanagawa, Japan

    Takashi Saito

  • London Research Institute, Cancer Research UK, London, United Kingdom

    Facundo D. Batista

Bibliographic Information

  • Book Title: Immunological Synapse

  • Editors: Takashi Saito, Facundo D. Batista

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-03858-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2010

  • Hardcover ISBN: 978-3-642-03857-0Published: 15 December 2009

  • Softcover ISBN: 978-3-642-26185-5Published: 01 March 2012

  • eBook ISBN: 978-3-642-03858-7Published: 03 December 2009

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XV, 255

  • Number of Illustrations: 5 b/w illustrations, 25 illustrations in colour

  • Topics: Immunology

Publish with us

Policies and ethics

Back to top

Search

Navigation