Behavioral Neurobiology of Anxiety and Its Treatment

1. Front Matter

   Pages i-xv

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2. Anxiety Disorders Diagnosis: Some History and Controversies

   • O. Joseph Bienvenu, Lisa A. Wuyek, Murray B. Stein

   Pages 3-19

3. Epidemiology of Anxiety Disorders

   • Ronald C. Kessler, Ayelet Meron Ruscio, Katherine Shear, Hans-Ulrich Wittchen

   Pages 21-35

4. Comorbidity in Anxiety Disorders

   • Kathleen Ries Merikangas, Sonja Alsemgeest Swanson

   Pages 37-59

5. Genetics

   • Katharina Domschke, Jürgen Deckert

   Pages 63-75

6. Neuroanatomy of Anxiety

   • Newton Sabino Canteras, Leonardo Barbosa Resstel, Leandro José Bertoglio, Antonio de Pádua Carobrez, Francisco Silveira Guimarães

   Pages 77-96

7. Stress and the Neuroendocrinology of Anxiety Disorders

   • Pêgo J. M, Sousa J. C, Almeida OFX, Sousa N

   Pages 97-118

8. Animal Models of Anxiety and Anxiolytic Drug Action

   • Dallas Treit, Elif Engin, Kris McEown

   Pages 121-160

9. Genetic Approaches to Modeling Anxiety in Animals

   • Laura H. Jacobson, John F. Cryan

   Pages 161-201

10. Behavioral Correlates of Anxiety

    • Victoria Risbrough

    Pages 205-228

11. Challenging Anxiety: A Focus on the Specificity of Respiratory Symptoms

    • M. A. Van Duinen, V. Niccolai, E. J. L. Griez

    Pages 229-250

12. Functional Neuroanatomy of Anxiety: A Neural Circuit Perspective

    • Amit Etkin

    Pages 251-277

13. Pharmacological Enhancement of Behavioral Therapy: Focus on Posttraumatic Stress Disorder

    • Dennis C. Choi, Barbara O. Rothbaum, Maryrose Gerardi, Kerry J. Ressler

    Pages 279-299

14. The Pharmacology of Anxiety

    • C. Durant, D. Christmas, D. Nutt

    Pages 303-330

15. GABAA Receptor α2/α3 Subtype-Selective Modulators as Potential Nonsedating Anxiolytics

    • John R. Atack

    Pages 331-360

16. Antidepressant Treatment in Anxiety Disorders

    • Anton Y. Bespalov, Marcel M. van Gaalen, Gerhard Gross

    Pages 361-390

17. Metabotropic Glutamate Receptors: Their Therapeutic Potential in Anxiety

    • Will Spooren, Anne Lesage, Hilde Lavreysen, Fabrizio Gasparini, Thomas Steckler

    Pages 391-413

18. Developing Small Molecule Nonpeptidergic Drugs for the Treatment of Anxiety Disorders: Is the Challenge Still Ahead?

    • Thomas Steckler

    Pages 415-428

19. Cannabinoids and Anxiety

    • Fabrício A. Moreira, Carsten T. Wotjak

    Pages 429-450

20. Pharmacological Treatment of Generalized Anxiety Disorder

    • David S. Baldwin, Khalil I. Ajel, Matthew Garner

    Pages 453-467

The book is part of a series on Current Topics in Behavioral Neurosciences, which has as its focus anxiety and its treatment. We have brought together a distinguished cadre of authors with the aim of covering a broad array of topics related to anxiety disorders, ranging from clinical diagnosis, epidemiology, preclinical neuroscience, and animal models to established and innovative therapeutic approaches. The book aims at bridging these disciplines to provide an update of literature relevant to understanding anxiety, its consequences, and its management. Following is a brief overview of the chapters and their content, meant to serve as a guide to navigating the book. The ?rst section covers clinical aspects of anxiety disorders. Joe Bienvenu and colleagues provide an incisive overview of diagnostic considerations in the anxiety disorders in which they emphasize the strengths and shortcomings of our current nosologic systems. This is followed by a review and update of the epidemiology of anxiety disorders by Ron Kessler and colleagues, which provides an authoritative survey of anxiety disorder incidence, prevalence, and risk factors. This is comp- mented by a comprehensive review of the literature on disorders that co-occur with anxiety disorders by Kathleen Merikangas and Sonja Alsemgeest Swanson. Their review highlights the tremendous comorbidity that occurs not only within the anxiety disorders, but also with other mental and physical health conditions.

• Cannabinoid
• Neurobiology
• anatomy
• anxiety
• diagnosis
• genetics
• neuroimaging

• Dept. Psychiatry, University of California, San Diego, La Jolla, USA

  Murray B. Stein

• Research & Development, CNS - Affective Spectrum, Johnson & Johnson Pharmaceutical, Beerse, Belgium

  Thomas Steckler

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