Disposable Bioreactors

1. Front Matter

   Pages i-xiii

   PDF

2. Disposable Bioreactors: Maturation into Pharmaceutical Glycoprotein Manufacturing

   • René Brecht

   Pages 1-31

3. Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale

   • Xiaowei Zhang, Matthieu Stettler, Dario De Sanctis, Marco Perrone, Nicola Parolini, Marco Discacciati et al.

   Pages 33-53

4. Bag Bioreactor Based on Wave-Induced Motion: Characteristics and Applications

   • Regine Eibl, Sören Werner, Dieter Eibl

   Pages 55-87

5. Disposable Bioreactors for Plant Micropropagation and Mass Plant Cell Culture

   • Jean-Paul Ducos, Bénédicte Terrier, Didier Courtois

   Pages 89-115

6. Transport Advances in Disposable Bioreactors for Liver Tissue Engineering

   • Gerardo Catapano, John F. Patzer II, Jörg Christian Gerlach

   Pages 117-143

7. Sensors in Disposable Bioreactors Status and Trends

   • Anne Glindkamp, Daniel Riechers, Christoph Rehbock, Bernd Hitzmann, Thomas Scheper, Kenneth F. Reardon

   Pages 145-169

8. Disposables in Downstream Processing

   • Uwe Gottschalk

   Pages 171-183

9. Hybrid and Disposable Facilities for Manufacturing of Biopharmaceuticals: Pros and Cons

   • Aline Ravisé, Emmanuelle Cameau, Georges De Abreu, Alain Pralong

   Pages 185-219

10. Back Matter

    Pages 221-223

    PDF

Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.

• Biochemistry
• Bioreactor
• Biotechnology
• Downstream Processing
• Pharmaceuticals
• Therapeutics
• Tissue Engineering
• Transport
• carbohydrate chemistry

• Hochschule Wädenswil, Wädenswil, Switzerland

  Regine Eibl, Dieter Eibl

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