Editors:
- Provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs)
- Main focus is on idiosyncratic drug reactions
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 196)
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Table of contents (19 chapters)
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Front Matter
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Target Organ Toxicity
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Front Matter
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Mediators/Biochemical Pathways
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Front Matter
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About this book
This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.
Editors and Affiliations
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Faculty of Pharmacy, University of Toronto, Toronto, Canada
Jack Uetrecht
Bibliographic Information
Book Title: Adverse Drug Reactions
Editors: Jack Uetrecht
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-642-00663-0
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2010
eBook ISBN: 978-3-642-00663-0Published: 18 December 2009
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: X, 556
Number of Illustrations: 4 illustrations in colour
Topics: Pharmacology/Toxicology, Immunology, Public Health, Hepatology, Dermatology, Allergology