Skip to main content
SpringerLink
Log in
Book cover

Toll-like Receptors: Roles in Infection and Neuropathology

  • Book
  • © 2009

Overview

Editors:
  1. Tammy Kielian

    1. Dept. Pathology & Microbiology, University of Nebraska Medical Center, Omaha, U.S.A.

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 336)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (10 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Overview of Toll-Like Receptors in the CNS

    • Tammy Kielian
    Pages 1-14

  3. Toll-Like Receptors in Bacterial Meningitis

    • Uwe Koedel
    Pages 15-40

  4. Toll-Like Receptors in Brain Abscess

    • Nilufer Esen, Tammy Kielian
    Pages 41-61

  5. Toll-Like Receptors in CNS Viral Infections

    • Hyeon-Sook Suh, Celia F. Brosnan, Sunhee C. Lee
    Pages 63-81

  6. Toll-Like Receptors in CNS Parasitic Infections

    • Bibhuti B. Mishra, Uma Mahesh Gundra, Judy M. Teale
    Pages 83-104

  7. Toll-Like Receptors in Neurodegeneration

    • Trevor Owens
    Pages 105-120

  8. Toll-Like Receptors in Spinal Cord Injury

    • Kristina A. Kigerl, Phillip G. Popovich
    Pages 121-136

  9. Toll-Like Receptors in Alzheimer's Disease

    • Gary E. Landreth, Erin G. Reed-Geaghan
    Pages 137-153

  10. Toll-Like Receptors in Multiple Sclerosis

    • Michael K. Racke, Paul D. Drew
    Pages 155-168

  11. Toll-Like Receptors in Peripheral Nerve Injury and Neuropathic Pain

    • Donghoon Kim, Soojin Lee, Sung Joong Lee
    Pages 169-186

  12. Back Matter

    Pages 187-191
    Download chapter PDF
Back to top

Keywords

About this book

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.

Editors and Affiliations

  • Dept. Pathology & Microbiology, University of Nebraska Medical Center, Omaha, U.S.A.

    Tammy Kielian

Bibliographic Information

  • Book Title: Toll-like Receptors: Roles in Infection and Neuropathology

  • Editors: Tammy Kielian

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-00549-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2009

  • Hardcover ISBN: 978-3-642-00548-0Published: 28 August 2009

  • Softcover ISBN: 978-3-642-26911-0Published: 14 March 2012

  • eBook ISBN: 978-3-642-00549-7Published: 19 August 2009

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 191

  • Number of Illustrations: 8 illustrations in colour

  • Topics: Neurosciences, Virology, Immunology, Parasitology

Publish with us

Policies and ethics

Back to top

Search

Navigation