Toll-like Receptors: Roles in Infection and Neuropathology

1. Front Matter

   Pages i-xi

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2. Overview of Toll-Like Receptors in the CNS

   • Tammy Kielian

   Pages 1-14

3. Toll-Like Receptors in Bacterial Meningitis

   • Uwe Koedel

   Pages 15-40

4. Toll-Like Receptors in Brain Abscess

   • Nilufer Esen, Tammy Kielian

   Pages 41-61

5. Toll-Like Receptors in CNS Viral Infections

   • Hyeon-Sook Suh, Celia F. Brosnan, Sunhee C. Lee

   Pages 63-81

6. Toll-Like Receptors in CNS Parasitic Infections

   • Bibhuti B. Mishra, Uma Mahesh Gundra, Judy M. Teale

   Pages 83-104

7. Toll-Like Receptors in Neurodegeneration

   • Trevor Owens

   Pages 105-120

8. Toll-Like Receptors in Spinal Cord Injury

   • Kristina A. Kigerl, Phillip G. Popovich

   Pages 121-136

9. Toll-Like Receptors in Alzheimer's Disease

   • Gary E. Landreth, Erin G. Reed-Geaghan

   Pages 137-153

10. Toll-Like Receptors in Multiple Sclerosis

    • Michael K. Racke, Paul D. Drew

    Pages 155-168

11. Toll-Like Receptors in Peripheral Nerve Injury and Neuropathic Pain

    • Donghoon Kim, Soojin Lee, Sung Joong Lee

    Pages 169-186

12. Back Matter

    Pages 187-191

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Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.

• Alzheimer
• Alzheimer's disease
• CNS parasitic infections
• CNS viral infections
• Nervous System
• bacterial meningitis
• brain abscess
• endogenous ligand
• infections
• infectious disease
• multiple sclerosis
• peripheral nerve injury
• spinal cord injury

• Dept. Pathology & Microbiology, University of Nebraska Medical Center, Omaha, U.S.A.

  Tammy Kielian

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