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Vaccines for Pandemic Influenza

  • Book
  • © 2009

Overview

Editors:
  1. Richard W. Compans

    1. School of Medicine, Emory University, Atlanta, U.S.A.

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    You can also search for this editor in PubMed   Google Scholar

  2. Walter A. Orenstein

    1. School of Medicine, Emory University, Atlanta, U.S.A.

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 333)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Pandemic Influenza Overview

    1. Front Matter

      Pages 1-1
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    2. Pandemic Influenza as a Current Threat

      • Hui-Ling Yen, Robert G. Webster
      Pages 3-24

    3. Antigenic Cross-Reactivity Among H5N1 Viruses

      • Adrianus C. M. Boon, Richard J. Webby
      Pages 25-40

  3. Current Approaches for Human and Avian Vaccine Production

    1. Front Matter

      Pages 42-42
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    2. Seasonal Influenza Vaccines

      • Anthony E. Fiore, Carolyn B. Bridges, Nancy J. Cox
      Pages 43-82

    3. Generation and Characterization of Candidate Vaccine Viruses for Prepandemic Influenza Vaccines

      • Eduardo O’Neill, Ruben O. Donis
      Pages 83-108

    4. Live Attenuated Vaccines for Pandemic Influenza

      • Grace L. Chen, Kanta Subbarao
      Pages 109-132

    5. Influenza Vaccines for Avian Species

      • Darrell R. Kapczynski, David E. Swayne
      Pages 133-152

    6. Development and Application of Avian Influenza Vaccines in China

      • Hualan Chen, Zhigao Bu
      Pages 153-162

  4. Novel Vaccine Approaches

    1. Front Matter

      Pages 164-164
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    2. Designing Vaccines for Pandemic Influenza

      • Taisuke Horimoto, Yoshihiro Kawaoka
      Pages 165-176

    3. Attenuated Influenza Virus Vaccines with Modified NS1 Proteins

      • Jüergen A. Richt, Adolfo García-Sastre
      Pages 177-195

    4. DNA Vaccines Against Influenza Viruses

      • Jin Hyang Kim, Joshy Jacob
      Pages 197-210

    5. Recombinant Proteins Produced in Insect Cells

      • John Treanor
      Pages 211-225

    6. Influenza Neuraminidase as a Vaccine Antigen

      • Matthew J. Sylte, David L. Suarez
      Pages 227-241

    7. Recombinant Vectors as Influenza Vaccines

      • Sarah A. Kopecky-Bromberg, Peter Palese
      Pages 243-267

    8. Influenza Virus-Like Particles as Pandemic Vaccines

      • S. M. Kang, P. Pushko, R. A. Bright, G. Smith, R. W. Compans
      Pages 269-289

    9. Pandemic Influenza Vaccines

      • Lauren J. DiMenna, Hildegund C. J. Ertl
      Pages 291-321

    10. Adjuvants for Pandemic Influenza Vaccines

      • Robert L. Atmar, Wendy A. Keitel
      Pages 323-344
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Keywords

About this book

Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans, resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raises the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have little or no antigenic relationship to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop eff- tive vaccines for pandemic influenza viruses, and to overcome the limitations inh- ent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine prod- tion, which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inac- vated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines that are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated.

Editors and Affiliations

  • School of Medicine, Emory University, Atlanta, U.S.A.

    Richard W. Compans, Walter A. Orenstein

Bibliographic Information

  • Book Title: Vaccines for Pandemic Influenza

  • Editors: Richard W. Compans, Walter A. Orenstein

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-540-92165-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2009

  • Hardcover ISBN: 978-3-540-92164-6Published: 28 July 2009

  • Softcover ISBN: 978-3-642-24240-3Published: 29 November 2011

  • eBook ISBN: 978-3-540-92165-3Published: 18 September 2009

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XVIII, 512

  • Number of Illustrations: 21 b/w illustrations, 30 illustrations in colour

  • Topics: Virology, Pharmacology/Toxicology, Public Health, Immunology

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