Engineering of Stem Cells

1. Front Matter

   Pages i-xiii

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2. Adult Stem and Progenitor Cells

   • Martine Geraerts, Catherine M. Verfaillie

   Pages 1-21

3. Isolation and Enrichment of Stem Cells

   • Andreas Bosio, Volker Huppert, Susan Donath, Petra Hennemann, Michaela Malchow, Uwe A. O. Heinlein

   Pages 23-72

4. Transdifferentiation of Stem Cells: A Critical View

   • Ina Gruh, Ulrich Martin

   Pages 73-106

5. Stem Cells for Cardiac Regeneration by Cell Therapy and Myocardial Tissue Engineering

   • Jun Wu, Faquan Zeng, Richard D. Weisel, Ren-Ke Li

   Pages 107-128

6. Stem Cells and Scaffolds for Vascularizing Engineered Tissue Constructs

   • E. Luong, S. Gerecht

   Pages 129-172

7. Embryonic Stem Cells: Isolation, Characterization and Culture

   • Michal Amit, Joseph Itskovitz-Eldor

   Pages 173-184

8. Totipotency, Pluripotency and Nuclear Reprogramming

   • Shoukhrat Mitalipov, Don Wolf

   Pages 185-199

9. Large Scale Production of Stem Cells and Their Derivatives

   • Robert Zweigerdt

   Pages 201-235

10. Back Matter

    Pages 237-239

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I am very pleased to present this volume on engineering stem cells in Advances in Biochemical Engineering and Biotechnology. This volume stays abreast of recent developments in stem cell biology and the high expectations concerning the dev- opment of stem cell based regenerative therapies. Regenerative medicine is the focus of current biomedical research, with unique challenges related to scientific, technical and ethical issues of stem cell research, and the potential added value of connecting biomedicine with enabling techno- gies such as materials sciences, mechanical- and nano-engineering. Research activities in regenerative medicine include strategies in endogenous regeneration of injured or degenerated tissues by means of gene therapy or cell transplantation, as well as complex approaches to replace or reconstruct lost or malformed tissue structures, by applying tissue engineering approaches. In most cases, the speci- ized functional cell types of interest cannot be isolated from the diseased organ or expanded to a sufficient degree, and various stem and progenitor cell types rep- sent the only applicable cell source. In almost all cases, stem cells have to be engineered, sometimes for functional improvement, in many cases to produce large numbers of cells, and frequently to achieve efficient and specific differentiation in the cell type(s) of interest.

• Tissue Engineering
• biochemical engineering
• biochemistry
• biomedicine
• biotechnology
• cell biology
• cells
• chemistry
• gene therapy
• regenerative medicine
• tissue

• Leibnitz Res.Lab.Biotechnol., Hannover Medical School, Hannover, Germany

  Ulrich Martin

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